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Clinical Trial Summary

An open, multicenter, phase Ib/II study to evaluate the efficacy, safety and pharmacokinetics of CT041 autologous CAR T-cell injection in patients with advanced gastric/ gastroesophageal junction adenocarcinoma and pancreatic cancer


Clinical Trial Description

This study is an open, multicenter, Phase Ib/II clinical trial evaluating chimeric antigen receptor-modified autologous T cells targeting Claudin18.2 (CLDN18.2) (CT041 autologous CAR T) in subjects with CLDN18.2 expression-positive, advanced gastric/esophagogastric conjugate adenocarcinoma that has failed at least 2 prior lines therapy and advanced pancreatic cancer that has failed at least 1 prior line therapy. The purpose is to evaluate the efficacy, safety and pharmacokinetics There are two stages in the study. Phase Ib stage is dose escalation and dose expansion study, and Phase II stage is to verify the efficacy and safety of CT041 treatment. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04581473
Study type Interventional
Source CARsgen Therapeutics Co., Ltd.
Contact Lifeng Zhang, MD
Phone 86-21-64501828
Email lifengzhang@carsgen.com
Status Recruiting
Phase Phase 1/Phase 2
Start date October 23, 2020
Completion date June 30, 2038

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