Decitabine-primed Tandem CD19/CD20 CAR T Cells Plus Epigenetic Agents in Aggressive r/r B-NHL With Huge Tumor Burden
Refractory or Relapsed Aggressive r/r B-NHL With Huge Tumor Burden Clinical Trial
Official title: Treatment of Decitabine-primed Tandem Targeting CD19 and CD20 Chimeric Antigen Receptor T Cells Plus Epigenetic Agents in Aggressive Relapsed and/or Refractory Non-Hodgkin's Lymphoma Patients With Huge Tumor Burden
Clinical Trial Summary
This open-label, multi-cohorts, phase 1/2 study has the primary objective of comparing
decitabine-primed tandem CART 19/20 solo, with decitabine-primed tandem CART 19/20 plus
chidamide, decitabine-primed tandem CART 19/20 plus decitabine, and decitabine-primed tandem
CART 19/20 plus decitabine+chidamide in patients with aggressive B-NHL who were confirmed as
Relapsed and/or Refractory B cell Non-Hodgkin's Lymphoma with hugh tumor burden (Sum of the
Product of the perpendicular Diameters for multiple lesions, SPD ≥ 100cm^2 or the
largest-diameter of tumor ≥ 10 cm.).
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