Clinical Trials Logo

Clinical Trial Summary

Insertion of a central venous access device (CVAD) allows clinicians to easily access the circulation of a patient to administer life-saving interventions. Due to their invasive nature, CVADss are prone to complications such as infection, bacterial biofilm production, and catheter occlusion due to a thrombus. A CVAD is placed in up to 97% of patients in the intensive care unit, exposing this vulnerable population to risk of nosocomial infection and occlusion. Current standard of care involves use of normal saline (for CVCs and PICCs) or citrate (for hemodialysis catheters) as a catheter locking solution. CVAD complications remain a problem with current standard of care. 4% tetrasodium Ethylenediaminetetraacetic acid (EDTA) fluid (KiteLock Sterile Locking Solution) possesses antimicrobial, anti-biofilm, and anti-thrombotic properties and is approved by Health Canada as a catheter locking solution. As such, it may be superior CVC locking solution than the present normal saline or citrate lock. To our knowledge, the efficacy of an EDTA catheter locking solution has not yet been investigated in the intensive care patient population. Our team proposes to fill this knowledge gap by performing a multi-centre, cluster-randomized, crossover study evaluating the impact of KiteLock Sterile Locking Solution on a primary composite outcome of CLABSI, intraluminal occlusion, and alteplase use in the ICU of six ICU's compared to the standard of care saline lock.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT04548713
Study type Interventional
Source Fraser Health
Contact Marlena Ornowska
Phone 2363326575
Status Recruiting
Phase N/A
Start date March 22, 2022
Completion date December 31, 2024

See also
  Status Clinical Trial Phase
Active, not recruiting NCT04054128 - Bicarbonate vs Heparin Catheter Lock in Chronic Hemodialysis Patients Phase 4
Recruiting NCT05729321 - Lock sOlutiOnS for Epicutaneo-caval Catheters in Neonates: a "LOOSEN" Pilot Study
Recruiting NCT05334225 - Assessing the Knowledge and Self-confidence of Healthcare Workers to Perform Transurethral Catheterization: A Multicenter Survey
Completed NCT06106659 - Comparison of Clinical Outcomes of Mini Midline Catheters With Different Placement Sites: a Randomized Controlled Trial N/A
Completed NCT03655106 - Ultrasound Guided Catheter Length Survivability N/A
Not yet recruiting NCT06014099 - Research on the Application of Blood Collection Through Midline Catheters of Different Lengths N/A
Completed NCT03693755 - Dislocation Rates of Femoral Catheter Placed Sonographically Either In-plane or Out-of-plane N/A
Not yet recruiting NCT06019897 - Impact of Tubing Colonization on the Incidence of Central Venous Catheter Infection
Not yet recruiting NCT06149533 - Evaluate the Efficacy and Safety of Edoxaban on Prevention of Catheter-related Thrombosis (CRT) in Cancer Patients Phase 3
Completed NCT01465594 - Study Comparing Urinary Diversion (Transurethral/Suprapubic) After Radical Prostatectomy N/A
Recruiting NCT06001827 - SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study N/A
Completed NCT04569474 - Peripheral IV Dressing and Phlebitis in Patients From Amazon N/A
Completed NCT05814887 - Reduction of Mechanical IV Complication Using a New Medical Device N/A
Recruiting NCT05741866 - Novel Antimicrobial Dressing in Peripheral Intravenous Catheters (PIVCs) N/A
Completed NCT06312215 - Effect Of Open And Closed System Peripheral Catheters Used In Pediatric Services N/A
Recruiting NCT04359056 - Clinical Pharmacy for Patients With a PICC Line N/A
Not yet recruiting NCT05869877 - The PIV5Rights Safety and Quality Bundle N/A
Completed NCT04285775 - A Novel Device for Surveillance of Vascular Access Sites for Bleeding
Completed NCT05446987 - Position Change and Back Massage Versus Early Ambulation on Post Transfemoral Coronary Angiography Complications N/A
Not yet recruiting NCT05354921 - Indwelling vs Intermittent Catheterization Pilot Study N/A