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A Phase 1/ Phase 2 Study of TTHX1114(NM141) — INTREPID  

Endothelial Dysfunction Clinical Trial

Official title:
A Phase 1/ Phase 2 Study Evaluating the Safety and Efficacy of the Investigational New Drug TTHX1114(NM141) on the Regeneration of Corneal Endothelial Cells in Patients With Corneal Endothelial Dystrophies Following Intracameral Delivery

Clinical Trial Summary

Prospective, multicenter, randomized, masked, vehicle-controlled, dose-escalation study

Clinical Trial Description

This is a prospective, multi-center, randomized, masked, vehicle-controlled, dose-escalation study that will include an observational (no intervention) sub-study. Eligible subjects with moderate to severe corneal endothelial dystrophy (defined as Endothelial Cell Density < 2000 mm^2) in at least one eye will be enrolled and randomized. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04520321
Study type Interventional
Source Trefoil Therapeutics, Inc.
Contact
Status Completed
Phase Phase 1/Phase 2
Start date August 19, 2020
Completion date May 18, 2021
View Details
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