NBTXR3 Activated by Radiation Therapy for the Treatment of Locally Advanced or Borderline-Resectable Pancreatic Cancer

Stage III Pancreatic Cancer AJCC v8 Clinical Trial

Official title:

Phase I Study of NBTXR3 Activated by Radiotherapy for Locally Advanced or Borderline Resectable Pancreatic Ductal Adenocarcinoma

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04484909
• Other study ID #: 2019-1001
• Secondary ID: NCI-2020-0373120
• Status: Active, not recruiting
• Phase: Phase 1
• Start date: July 1, 2020
• Est. completion date: December 31, 2026

Study information

• Verified date: April 2024
• Source: M.D. Anderson Cancer Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To find the recommended dose of NBTXR3 that can be given in combination with radiation therapy to patients with pancreatic cancer. To learn if the dose NBTXR3 found in Part 1 can help to control the disease.

Description:

PRIMARY OBJECTIVE: • To determine the recommended phase II dose (RP2D) of NBTXR3 activated by radiotherapy in subjects with locally advanced or borderline-resectable pancreatic ductal adenocarcinoma. SECONDARY OBJECTIVES: - To evaluate the safety and feasibility of NBTXR3 intratumoral injection activated by radiotherapy in locally advanced or borderline-resectable pancreatic ductal adenocarcinoma - To evaluate the anti-tumor response of NBTXR3 intratumoral injection activated by radiotherapy in subjects with locally advanced or borderline-resectable pancreatic ductal adenocarcinoma - To evaluate time-to-event outcomes in subjects with locally advanced or borderline-resectable pancreatic ductal adenocarcinoma EXPLORATORY OBJECTIVES: - To evaluate the body kinetic profile of intratumorally injected NBTXR3. - To evaluate time to event outcomes for subjects with clinical staging of locally advanced, unresectable disease. - To evaluate resectability conversion rates. - To evaluate surgical outcomes in subjects who undergo surgery after radiation therapy. - To associate radiomic measurements with outcomes. - To evaluate biomarkers of response in subjects treated with NBTXR3/RT. OUTLINE: This is a dose-escalation study of NBTXR3. Patients receive NBTXR3 intratumorally (IT) on day 1. Patients then undergo 15 fractions of intensity modulated radiation therapy (IMRT) between days 15-43 in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 1 month and then every 3 months for up to 1 year.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 24
• Est. completion date: December 31, 2026
• Est. primary completion date: December 31, 2026
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Signed informed consent form (ICF) indicating that participant understands the purpose of, and procedures required for, the study and is willing to participate in the study 2. Age = 18 years 3. Biopsy proven ductal adenocarcinoma of the pancreas,as defined by the following: a. Borderline resectable pancreatic adenocarcinoma (BRPC) has no aortic involvement with at least ONE of the following features: i. Superior mesenteric vein (SMV) or Portal vein (PV) with a tumor interface of = 180° OR short segment occlusion of SMV or PV amenable to reconstruction ii. Superior mesenteric artery (SMA) or celiac axis (CA) with a tumor interface of < 180° iii. Any degree of hepatic artery interface that is amenable to reconstruction b. Locally advanced pancreatic adenocarcinoma (LAPC) has at least ONE of the

following features:

1. Signed informed consent form (ICF) indicating that participant understands the purpose of, and procedures required for, the study and is willing to participate in the study

2. Age = 18 years

3. Biopsy proven ductal adenocarcinoma of the pancreas,as defined by the following:

a. Borderline resectable pancreatic adenocarcinoma (BRPC) has no aortic involvement with at least ONE of the following features: i. Superior mesenteric vein (SMV) or Portal vein (PV) with a tumor interface of = 180° OR short segment occlusion of SMV or PV amenable to reconstruction ii. Superior mesenteric artery (SMA) or celiac axis (CA) with a tumor interface of < 180° iii. Any degree of hepatic artery interface that is amenable to reconstruction b. Locally advanced pancreatic adenocarcinoma (LAPC) has at least ONE of the following features: i. Occlusion of the SMV or PV that is not amenable to reconstruction ii. Tumor interface of the superior mesenteric artery or celiac axis = 180° iii. Involvement of the hepatic artery that is not amenable to reconstruction iv. Involvement of the aorta

4. Has had a 4-month course (± 2-months) of chemotherapy for PDAC without radiographic

evidence of distant metastatic disease. Following chemotherapy regimens are allowed:

1. gemcitabine/nab-paclitaxel

2. gemcitabine/capecitabine

3. gemcitabine/cisplatin

4. gemcitabine

5. FOLFOX

6. FOLFIRINOX

5. Amenable to undergo the endoscopic ultrasound guided injection of NBTXR3 as per investigator or treating physician.

6. Has a target lesion in the pancreas that is identifiable on cross sectional imaging by repeated measurements (via RECIST 1.1) at the same anatomical location a. Nodal disease only is not allowed.

7. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1

8. Laboratory Values at screening:

1. Hemoglobin = 8.0 g/dL

2. Absolute Neutrophil Count (ANC) = 1,500/mm3

3. Platelet Count = 100,000/mm3

4. Creatinine = 1.5 x upper limit of normal (ULN)

5. Total Bilirubin = 2.0 mg/dL

6. AST / ALT = 3.0 x upper limit of normal (ULN)

7. Serum albumin = 3.0 g/dL

9. Negative pregnancy test = 7 days prior to NBTXR3 injection in all females of child-bearing potential

10. If participant has a history of prior duodenal or biliar plastic stent, it should be replaced with a metal stent = 1 week prior to Study Day 1.

Exclusion Criteria:

1. Prior radiation therapy to the upper abdomen

2. Prior surgical resection of pancreatic tumor

3. Diagnosis other than pancreatic ductal adenocarcinoma. All other histologic types (i.e., adenosquamous, cystadenocarcinoma, etc.) are not eligible to participate on this study.

4. LAPC or BRPC with radiographic evidence of distant metastasis at screening.

5. Has received any approved or investigational anti-neoplastic agent other than the chemotherapies specified in this protocol (i.e. chemotherapies included in Inclusion #4)

6. Known uncontrolled (Grade = 2) or active gastric or duodenal ulcer disease within 30 days of enrollment

7. Known contraindication to iodine-based or gadolinium-based IV contrast

8. Active malignancy, in addition to pancreatic cancer, with the exception of basal cell carcinoma of the skin definitively treated and relapse free within at least 1 year from diagnosis

9. Clinically significant cardiac arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes, second or third degree atrioventricular heart block without a permanent pacemaker in place)

10. Class III or IV Congestive Heart Failure as defined by the New York Heart Association functional classification system <6 months prior to screening

11. Known active, uncontrolled (high viral load) HIV or hepatitis B or hepatitis C infection a. Patients who have been vaccinated for hepatitis B and do not have a history of infection are eligible.

12. Female patients who are pregnant or breastfeeding

13. Women of child-bearing potential and their male partners who are unwilling or unable to use an acceptable method of birth control for the entire study period. Acceptable methods of contraception are those that, alone or in combination, result in a failure rate of < 1% per year when used consistently and correctly

14. Any condition for which, in the opinion of the investigator, participation would not be in the best interest of the participant (e.g., compromise the well-being) or that could prevent, limit, or confound the protocol-specified assessments

Related Conditions & MeSH terms

• Adenocarcinoma
• Borderline Resectable Pancreatic Adenocarcinoma
• Locally Advanced Pancreatic Ductal Adenocarcinoma
• Pancreatic Neoplasms
• Resectable Pancreatic Ductal Adenocarcinoma
• Stage III Pancreatic Cancer AJCC v8

Intervention

Other:
• Hafnium Oxide-containing Nanoparticles NBTXR3
Given IT

Radiation:
• Radiation Therapy
Undergo radiation therapy

Locations

Country	Name	City	State
United States	M D Anderson Cancer Center	Houston	Texas

Sponsors (2)

Lead Sponsor	Collaborator
M.D. Anderson Cancer Center	National Cancer Institute (NCI)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Presence of hafnium	Will evaluation of the time-course dependent presence of hafnium in blood and urine following NBTXR3 intratumoral injection.	Up to 1 year
Other	Disease control rate	Defined as the proportion of patients without progression 6 months post NBTXR3 injection.	6 months
Other	Proportion of locally advanced subjects who undergo surgical resection after receiving NBTXR3/radiation therapy (R3/RT)		Up to 1 year
Other	Resection status	Resection status as assessed macroscopically by surgeon R0- Macroscopically complete tumor removal with negative microscopic surgical margins, R1- Macroscopically complete tumor removal with positive microscopic margins (any or all), and R2- Macroscopically incomplete tumor removal with known or suspected residual gross disease.	Up to 1 year
Primary	Dose-limiting toxicities	Any grade >= 3 adverse event related to NBTXR3 and/or radiation therapy. Any toxicity (grade >= 3) that is at least possibly related to study drug (NBTXR3) is a DLT. Adverse events will be scored based on National Cancer Institute - Common Terminology Criteria for Adverse Events (NCI-CTCAE v 5.0).	4 weeks after last radiation dose
Primary	Maximum tolerated dose (MTD)	MTD will be determined as the dose for which the isotonic estimate of the toxicity rate is closest to the target toxicity rate 30%.	Up to 1 year
Primary	Recommended phase II dose (RP2D)		Up to 1 year
Secondary	Determination of the feasibility of NBTXR3 injection in pancreas	Feasibility refers to the ability to do intratumoral injection of NBTXR3. The outcome for each patient would be "feasible" or "not feasible."	Up to 1 year
Secondary	Progression free survival (PFS)		From NBTXR3 injection to local recurrence, local progression, distant progression, or death from any cause, whichever occurs first, assessed up to 1 year
Secondary	Overall survival (OS)		From NBTXR3 injection to death from any cause or EoS, whichever occurs first, assessed up to 1 year

External Links

•   MD Anderson Cancer Center