| Eligibility |
Inclusion Criteria:
- Has a histologically-confirmed or cytologically confirmed diagnosis of stage IV
squamous NSCLC.
- No known epidermal growth factor receptor (EGFR) mutations.
- Has measurable disease.
- Has not received prior systemic treatment for their advanced/metastatic NSCLC.
- Can provide tumor tissue.
- Has a life expectancy of at least 3 months.
- Has a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
Performance Status.
- Has adequate organ function
- If female of childbearing potential, have a negative serum pregnancy test within 7
days prior to first trial treatment;
- If female of childbearing potential or a male subject with a partner with childbearing
potential, be willing to use a highly effective method of contraception (with a
failure rate of less than 1.0% per year) from first study treatment to 24 weeks after
completion of the trial treatment.
Exclusion Criteria:
- Untreated active CNS metastasis or leptomeningeal metastasis.
- Is currently participating and receiving an investigational drug or has participated
in a study of an investigational drug within 4 weeks or within 5 times of half-life
(no less than 2 weeks), whichever is shorter prior to the first dose of trial
treatment;
- Has received other anti-tumor treatment within 4 weeks or within 5 times of half-life
(no less than 2 weeks), whichever is shorter prior to the first trial treatment;
- Major surgery for any reason, except diagnostic biopsy, within 4 weeks of the first
administration of trial treatment and/or if the subject has not fully recovered from
the surgery within 4 weeks of the first administration of trial treatment;
- Curative radiation within 3 months of the first dose of trial treatment. Radiation to
more than 30% of the bone marrow or with a wide field of radiation should not be used
within 4 weeks prior to the first administration of trial treatment;
- Subjects receiving immunosuppressive agents (such as steroids) for any reason should
be tapered off these drugs before initiation of trial treatment (with the exception of
subjects with adrenal insufficiency, who may continue corticosteroids at physiologic
replacement doses, equivalent to < 10 mg prednisone daily, inhaled steroids and
topical use of steroids);
- Vaccination within 28 days of the first administration of trial treatment, except for
administration of inactivated vaccines (e.g., inactivated influenza vaccines);
- Has interstitial lung disease, or a history of pneumonitis that required oral or
intravenous glucocorticoids to assist with management;
- History or current active autoimmune disease that might deteriorate when receiving an
immunostimulatory agent
- Previous malignant disease
- History of uncontrolled intercurrent illness
- Prior therapy with any antibody/drug targeting T cell coregulatory proteins
- Known severe hypersensitivity reactions to antibody drug
- Is pregnant or breastfeeding;
- Other medical conditions that at the discretion of investigator interfere with the
requirements of the trial in terms of safety or efficacy evaluation, or treatment
compliance.
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