Efficacy and Safety of CRT, Durvalumab and Surgery for SST

Non Small Cell Lung Cancer Stage III Clinical Trial

— DEEP_OCEAN  

Official title:

Efficacy and Safety of Durvalumab Before and After Operation or Durvalumab as Maintenance Therapy After Chemoradiotherapy Against Superior Sulcus Non-small Cell Lung Cancer

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04465968
• Other study ID #: JCOG1807C
• Status: Not yet recruiting
• Phase: Phase 3
• Start date: September 1, 2020
• Est. completion date: August 31, 2030

Study information

• Verified date: July 2020
• Source: National Cancer Center Hospital East
• Contact: Masahiro Tsuboi, MD
• Phone: +81-4-7133-1111
• Email: mtsuboi[@]east.ncc.go.jp
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The safety and efficacy of multimodality treatment of pre- and post-operative durvalumab therapy after pre-operative chemoradiotherapy for resectable superior sulcus tumor (SST) and durvalumab maintenance therapy after chemoradiotherapy for unresectable SST

Description:

To evaluate the safety and efficacy of multimodality treatment of pre- and post-operative durvalumab therapy after pre-operative chemoradiotherapy for resectable superior sulcus tumor (SST) and durvalumab maintenance therapy after chemoradiotherapy for unresectable SST

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 84
• Est. completion date: August 31, 2030
• Est. primary completion date: August 31, 2027
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 75 Years

Eligibility

Inclusion Criteria:

1. A definite diagnosis of non-small cell lung cancer has been obtained by biopsy from the primary lesion.

2. Meet all of the following (UICC-TNM classification 8th edition). I. Regarding the primary lesion, meet one of the following on chest CT. i. Direct invasion of the chest wall at or above the height of the first rib (at least invasion of the parietal pleura) ii. Direct invasion of the subclavian artery or vein II. Regarding regional lymph nodes, meet either of the following by chest CT and FDG-PET/CT. Metastasis is also considered if lymph node metastasis is determined by either chest CT or FDG-PET/CT.

i. cN0 ii. cN1 and no metastases to #10, #11, and #12 lymph nodes iii. cN3 (ipsilateral supraclavicular lymph node metastasis) and no metastases in regional lymph nodes (N1 and N2) other than "#13, #14 lymph nodes" III. No distant metastases (including intrapulmonary metastases in the same ling lobe and in a different lung lobe on the same side) on imaging tests including FDG-PET/CT

3. It is judged that radical resection is possible by lobectomy (including bilobectomy for 2 lobes), which satisfies the following [1] and [2].

I. The board respiratory surgeon judges that none of the following is true based on the image findings.

i. There is vertebral body infiltration that requires total spondylectomy ii. Presence of spinal cord infiltration iii. Invaded trachea or tracheal bifurcation iv. Invasion of aortic arch or ascending aorta v. Invading brachial plexus at C8 or higher vi. Esophageal infiltration that requires esophageal reconstruction for resection vii. Pneumonectomy is required for radical resection II. Meet all of the following. i. Predicted postoperative forced expiratory volume of 1 second (FEV1.0) = 800 mL within 56 days before registration ii. SpO2 > 93% (room air) with the latest inspection value within 14 days before registration

4. Consult with the radiotherapy doctor and it is judged that all of the following are met.

I. Radiation therapy is possible according to the protocol II. The irradiation field does not reach the hilum

5. The age of the registration date is 20 years or older and 75 years or yonger.

6. Performance status (PS) is 0 or 1 according to ECOG standards (PS must be described in medical records)

7. The presence or absence of measurable lesions is not required.

8. No history of following surgery irrespective of whether for a benign or malignant lesion.

I. Thoracoscopic surgery or thoracotomy with excision of the affected lung or esophagus or mediastinum (however, a history of thoracoscopic surgery without wedge resection or lung, esophagus, or mediastinal resection (eg, pleural biopsy)) is allowed) II. Median sternotomy surgery (with or without organ resection) III. Pulmonary resection other than wedge resection of the contralateral lung (whether open-heart surgery or thoracoscopic surgery)

9. There is no history of chemotherapy, including treatment for other cancer types (including molecular targeted therapies and immune checkpoint inhibitors). However, the history of drug therapy as adjuvant therapy is allowed if it was completed more than 3 years ago. In addition, a history of hormone therapy for other cancer types is allowed.

10. If there is a history of radiotherapy including other cancer types, the lung, hilum, mediastinum, and supraclavicular fossa are not included in the irradiation field.

11. Chest CT does not show interstitial pneumonia or pulmonary fibrosis.

12. No history of complication of autoimmune disease or chronic or recurrent autoimmune disease. However, patients with type 1 diabetes which is well controlled by appropriate treatment, hyperthyroidism/hypothyroidism that requires only antithyroid drug/hormone replacement therapy, autoimmune skin disease that does not require systemic treatment (Pemphigus, psoriasis vulgaris, pemphigus vulgaris, vitiligo), and celiac disease controlled only by dietary control are regarded as eligible if they have been inactive in the past 5 years, even with a history of autoimmune complications or history.

13. No surgical treatment with general anesthesia within 14 days (2 weeks) before registration.

14. No systemic administration of steroids, other immunosuppressive drugs, or immunoglobulins within 28 days (4 weeks) before registration. However, those that meet the following conditions are allowed.

I. Intranasal/inhalation/topical steroid injection or local steroid injection (for example, intra-articular injection) II. Systemic administration of steroid drugs at a dose of 10 mg/day or less in terms of prednisolone III. Steroids as premedication (eg CT premedication)

15. Can be taken orally.

16. No ischemic changes were observed on the latest 12-lead ECG within 28 days before registration. However, if a 12-lead electrocardiogram shows ischemic changes, echocardiography, exercise electrocardiography, etc. should be performed, and if it is judged that new treatment for ischemic heart disease is not necessary, it is qualified.

17. The latest inspection value within 14 days before registration (possible on the same day two weeks before the registration date) satisfies all of the following.

I. White blood cell count ?4,000/mm3 II. Hemoglobin = 11.0 g/dL (no blood transfusion within 14 days before the blood sampling date of the test used for registration) III. Platelet count ?10×104 /mm3 IV. Total bilirubin = 2.0 mg/dL V. AST = 75 U/L VI. ALT = 75 U/L VII. Serum creatinine = 1.2 mg/dL

18. Written informed consent from the patient to participate in the study.

19. The attending physician can judge that the enrolled patients understand the treatment and evaluation schedule of this study and can comply with them.

Exclusion Criteria:

1. Having active double cancer (simultaneous double cancer/multiple cancer and metachronous double cancer/multiple cancer with a disease-free period of 3 years or less, even if the disease-free period is less than 3 years, clinical The 5-year relative survival rate is similar to that of stage I prostate cancer, clinical stage 0 completely responded to radiation therapy, stage I laryngeal cancer, and complete excision of the following pathological stage cancers. History of cancer equivalent to 95% or more is not included in active double cancer/multiple cancer). Gastric cancer "adenocarcinoma (general type)": Stage 0-I, colon cancer (adenocarcinoma): Stage 0-I, rectal cancer (adenocarcinoma): Stage 0-I, esophageal cancer (squamous cell carcinoma, glandular) Squamous cell carcinoma, basal cell carcinoma): Stage 0, breast cancer (non-invasive ductal carcinoma, lobular carcinoma): Stage 0, breast cancer (invasive ductal carcinoma, lobular invasive carcinoma, Paget's disease): 0 Stage-IIA, endometrial cancer (endometrioid adenocarcinoma, mucinous adenocarcinoma): Stage I, prostate cancer (adenocarcinoma): Stage I-II, cervical cancer (squamous cell carcinoma): Stage 0, thyroid cancer (Papillary cancer, follicular cancer): stage I, stage II, stage III, renal cancer (clear cell carcinoma, chromophobe cell carcinoma): stage I, non-melanoma skin cancer, malignant melanoma without a definite diagnosis, etc. Lesions of intramucosal cancer

2. Has an infectious disease that requires systemic treatment (including active pulmonary tuberculosis).

3. When registering, a fever of 38.0°C or higher is generated.

4. Women who are pregnant, possibly pregnant, within 28 days of delivery, or breastfeeding. A man who wants a partner to become pregnant. Or a reproductive male or female patient who is not willing to use an effective contraceptive by Week 13 (Day 91) after the last dose of durvalumab (see 6.4.7.).

5. Participation in the study is considered to be difficult due to the combination of mental illnesses or symptoms that impair daily life.

6. Continuous systemic administration (oral or intravenous) of steroid drugs or other immunosuppressive drugs in excess of 10 mg/day in terms of prednisolone.

7. With uncontrolled diabetes.

8. With uncontrolled hypertension.

9. A gastrointestinal disorder accompanied by uncontrolled diarrhea.

10. With unstable angina (angina with onset or exacerbation of attack within the last 3 weeks) or a history of myocardial infarction within 6 months.

11. Poor valvular heart disease, dilated cardiomyopathy, hypertrophic cardiomyopathy, congestive heart failure, and arrhythmia.

12. Chest CT reveals severe emphysema.

13. Either HBs antigen, HCV antibody, or HIV1/2 antibody is positive.

14. Continuous use of flucytosine (Ancotil®) is required.

15. Participating in another clinical trial (excluding observational studies) during the 6 months prior to enrollment.

16. A history of allogeneic organ transplant.

17. A history of active primary immunodeficiency.

18. Live vaccines (BCG, polio, measles-rubella mixture, measles, rubella, mumps, chickenpox, yellow fever, rotavirus, etc.) have been administered within 30 days before registration.

19. Has hypersensitivity or allergy to the test drug or its additives used in this test.

Related Conditions & MeSH terms

• Carcinoma, Non-Small-Cell Lung
• Lung Neoplasms
• Non Small Cell Lung Cancer Stage III
• Non-small Cell Lung Cancer Stage IIB
• Superior Sulcus Tumor

Intervention

Drug:
• Cisplatin
Cisplatin 60 mg/m2, IV, day 1
• S1
80 - 120 mg/day, PO, day 1-14

Radiation:
• concurrent radiotherapy
66 Gy/33 Fr

Drug:
• Durvalumab
preoperative durvalumab therapy within 28 days after chemoradiotherapy. Two courses are given every two weeks.

Procedure:
• Surgery
Surgery will be performed between day 15 and day 42 of the second course of preoperative durvalumab therapy after confirming that all surgical operation criteria are met.

Drug:
• Durvalumab
(For resectable SST) Postoperative durvalumab therapy will be started between day 28 and day 63 with the day of surgery as Day 1. Twenty-two courses are given as a 2-week course. Drug: Durvalumab 10 mg/kg/body, IV, day 1 (For unreectable SST) Additional durvalumab therapy between day 15 and day 28 of the second course of preoperative durvalumab therapy. Twenty-two courses are given as 2-week course. Drug: Durvalumab 10 mg/kg/body, IV, day 1

Locations

Country	Name	City	State
n/a

Sponsors (4)

Lead Sponsor	Collaborator
National Cancer Center Hospital East	AstraZeneca, Japan Agency for Medical Research and Development, Japan Clinical Oncology Group

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	3-year overall survival rate (3y-OS)	3-year overall survival rate	3 years
Secondary	3-year progression-free survival rate (3y-PFS)	3-year progression-free survival rate	3 years
Secondary	5-year progression-free survival rate (5y-PFS)	5-year progression-free survival rate	5 years
Secondary	5-year overall survival rate (5y-OS)	5-year overall survival rate	5 years
Secondary	Mode of recurrence	Mode of recurrence in surgical cases	5 years
Secondary	Local recurrence rate	Proportion of local failure in surgical cases	5 years
Secondary	Objective response rate (ORR)	Objective response rate according to RECIST and iRECIST	1 year 6 months
Secondary	Resection rate	Proportion of surgical cases	1 year 6 months
Secondary	Pathological complete resection rate (R0 rate)	Proportion of pathologcal complete resection in surgical cases	1 year 6 months
Secondary	Pathological complete response rate (pCR rate)	Proportion of pathologcal complete response in surgical cases	1 year 6 months
Secondary	Major pathological response rate (MPR rate)	Determination of major pathologic response rate is based on the method by Hellmann et al. on the pathological section. The percentage of residual tumor cells is calculated as viable tumor cells / tumor area × 100 (%). Tumor area includes viable tumor cells and interstitial tissue such as fibrosis, necrosis, and inflammatory cells.	1 year 6 months
Secondary	Operation time	Operation time in surgical cases	1 year 6 months
Secondary	Blood loss	Intraoperative blood loss in surgical cases	1 year 6 months
Secondary	Adverse event rate		1 year 6 months
Secondary	Incidences of serious adverse events		1 year 6 months
Secondary	Incidences of adverse events		1 year 6 months