Pathogenic Microorganisms in Adult Severe Pneumonia Patients

Pathogenic Microorganism of Serious Pneumonia Clinical Trial

Official title:

A Multicenter Clinical Study on the Detection of Pathogenic Microorganisms in Adult Severe Pneumonia Patients in Liaoning Province

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04433403
• Other study ID #: PMASP
• Status: Active, not recruiting
• Start date: July 1, 2020
• Est. completion date: June 30, 2024

Study information

• Verified date: September 2021
• Source: Shengjing Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study aimed to evaluate pathogenic microorganisms in adult severe pneumonia patients in different cities of Liaoning Province

Description:

The pathogenic microorganisms of adult patients with severe pneumonia is detected in this study. Clinical treatment does not involve , so it meets the ethical requirements. The clinical data, laboratory test results and imaging data of adult severe pneumonia patients in different hospitals in different cities are recorded. The pathogenic microorganism is detected by second-generation sequencing of lower respiratory tract sputum or alveolar lavage fluid samples, and the data were sorted out to draw the pathogenic microorganism spectrum of adult severe pneumonia in Liaoning area. It will be used to guide clinical empirical treatment.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 300
• Est. completion date: June 30, 2024
• Est. primary completion date: December 31, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Meet the standard of severe pneumonia: Main standards: Requiring mechanical ventilation or septic shock requiring vasoconstrictor therapy.

Secondary standards:(only if 3 items are met) Disturbance of consciousness; respiratory rate = 30 times/min; PaO2/FiO2 = 250, or PaO2 < 60mmHg; azotemia (BUN = 7.12mmol / L); hypotension requires strong fluid resuscitation; infiltration of multiple lobes; leucopenia (WBC < 4 × 109 / L); thrombocytopenia (< 10 × 109 / L); hypothermia (T < 36 ?).

Exclusion Criteria:

• refuse to sign informed consent; inaccurate results due to unqualified sputum or BALF samples

Related Conditions & MeSH terms

• Pathogenic Microorganism of Serious Pneumonia
• Pneumonia

Intervention

Other:
• pathogenic microorganism
Detection of pathogenic microorganisms in adult severe pneumonia by second generation sequencing

Locations

Country	Name	City	State
China	Shengjing hospital of China Medical University	Shenyang	Liaoning

Sponsors (7)

Lead Sponsor	Collaborator
Shengjing Hospital	Benxi Cental Hospital, Chaoyang Central Hospital, Dandong First Hospital, Fushun Mining Bureau General Hospital, Huludao central hospital, Yingkou Central Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pathogenic microorganism spectrum of adult severe pneumonia in Liaoning Province	Detection of pathogenic microorganisms in severe pneumonia by second generation sequencing	2020.7-2023.12