Effects of tDCS in M1 and DLPFC on Pain Processing in Healthy Volunteers

Pain Processing in Healthy Volunteers Clinical Trial

Official title:

Effects of Transcranial Direct Current Stimulation on Primary Cortex and Prefrontal Dorsolateral Cortex in Pain Processing on Healthy Volunteers: A Triple Blind Randomized Controlled Trial.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04432363
• Other study ID #: 30012020204820
• Status: Completed
• Phase: N/A
• Start date: June 6, 2020
• Est. completion date: July 25, 2020

Study information

• Verified date: October 2020
• Source: Universidad Rey Juan Carlos
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effects of a direct current applied transcranial over two cortical areas on healthy volunteers' pain processing.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: July 25, 2020
• Est. primary completion date: July 25, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Age between 18 and 40 years

• Comprehension of the study tasks

Exclusion Criteria:

• Presence of pain in the previous 6 months

• Altered sensitivity in the tested regions

• Intolerance to electrotherapy

• Presence of pacemakers or any other implanted device

• Ulcers or scars in the skin at the location of the electrodes

• Treatment with direct current stimulation within one week

• Pregnancy

• Frequent headaches

• Epilepsy

• History of neuromuscular disease

• Previous clinical history of cervical surgery

• Injuries or surgery affecting the upper limb

• diabetes mellitus

• Cardiovascular diseases

• Oncological diseases

• Consumption of analgesic drugs 7 days before the study

Related Conditions & MeSH terms

• Pain Processing in Healthy Volunteers

Intervention

Device:
• Transcranial direct current stimulation
Direct current application over the scalp to stimulate and change the excitability of the cortical areas underneath the electrodes (in this case left primary motor cortex and left dorsolateral prefrontal cortex).

Locations

Country	Name	City	State
Spain	Universidad Rey Juan Carlos	Alcorcon	Madrid

Sponsors (1)

Lead Sponsor	Collaborator
Universidad Rey Juan Carlos

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Conditioned Pain Modulation	Pain pressure threshold change after a painful ischemic stimulus	Pre-intervention and immediately after treatment
Primary	Pain pressure algometer temporal summation	Change in pain perceived between the first and tenth painful pressure stimulus	Pre-intervention and immediately after treatment
Secondary	Pain pressure threshold	Measurement of pressure applied until the perception of pain	Pre-intervention and immediately after treatment
Secondary	Pain pressure tolerance	Measurement of maximal painful pressure tolerate using a pressure algometer	Pre-intervention and immediately after treatment
Secondary	Neural mechanosensitivity	Measurement of range of motion achieved until the perception of tension	Pre-intervention and immediately after treatment
Secondary	Cold hyperalgesia with a cold pack	Pain rated in a visual analogue scale after 10 seconds of a cold stimulus	Pre-intervention and immediately after treatment
Secondary	Isometric grip strength	Maximal pressure achieved in a isometric gripping task	Pre-intervention and immediately after treatment

External Links

•   Rey Juan Carlos University