Finding the Minimum Dose to Induce Sympathectomy in Infraclavicular Clinical Trial
Official title:
Looking for Minimum Dose to Induce Sympathectomy in Infraclavicular Brachial Plexus Block
| Verified date | June 2020 |
| Source | Taipei Medical University WanFang Hospital |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Observational |
For patients who undergoing hemodialysis, it is important to have good AV fistula. One third of AV fistula usually fail during early stage. It is helpful to use nerve block to dilate the blood vessels and enhance the prognosis. But 0.2% Ropivacaine usually cause muscle weakness in present studies. The investigators hope to find the lowest concentration to provide sympathectomy without muscle weakness. Because the patients with hemodialysis usually have multiple co-morbidity, thus we choose patients with forearm fracture at the first place. With this result, the investigators can design further study for patients with hemodialysis. The investigators prefer proximal approach because brachial plexus run together in the cosctoclavicular space and show lower incidence of incomplete work.
| Status | Not yet recruiting |
| Enrollment | 66 |
| Est. completion date | July 4, 2021 |
| Est. primary completion date | July 4, 2021 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years to 80 Years |
| Eligibility |
Inclusion Criteria: - Age between 20-80 y/o, BW: 40-90 kilograms,ASA class I-III,No pre-existing neuropathy,Scheduled for upper limb surgery. Exclusion Criteria: 1. Pre-existing neuropathy (ex: polyneuropathy) 2. History of allergy to xylocaine?ropivacaine?epinephrine 3. Emergent surgery 4. Coagulopathy 5. Patient who can not express themselves |
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| Taipei Medical University WanFang Hospital |
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Change of diameter of basilic vein and brachial artery | Use ultrasound to measure the difference of diameter at different time point. | Change from baseline diameter(pre-nerve block) at 45min | |
| Primary | Change of diameter of basilic vein and brachial artery | Use ultrasound to measure the difference of diameter at different time point. | Change from baseline diameter(pre-nerve block) at 24hour | |
| Primary | Change of diameter of basilic vein and brachial artery | Use ultrasound to measure the difference of diameter at different time point. | Change from baseline diameter(pre-nerve block) at 48hour | |
| Secondary | Sensory block of upper limb | A validated 3-point scale was used: 0 = no block (patient has normal sensation), 1 = patient can feel cold, but the sensation is reduced compared with the unblocked side, and 2 = complete anesthesia. | 45min post nerve block | |
| Secondary | Sensory block of upper limb | A validated 3-point scale was used: 0 = no block (patient has normal sensation), 1 = patient can feel cold, but the sensation is reduced compared with the unblocked side, and 2 = complete anesthesia. | 24hour post nerve block | |
| Secondary | Motor block of upper limb | A validated 3-point scale was used: 0 = no block (patient has normal power), 1 = patient can feel weakness with the unblocked side, and 2 = complete anesthesia. | 45min post nerve block | |
| Secondary | Motor block of upper limb | A validated 3-point scale was used: 0 = no block (patient has normal power), 1 = patient can feel weakness with the unblocked side, and 2 = complete anesthesia. | 24hour post nerve block | |
| Secondary | Motor block of upper limb | A validated 3-point scale was used: 0 = no block (patient has normal power), 1 = patient can feel weakness with the unblocked side, and 2 = complete anesthesia. | 48hour post nerve block |