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Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients — VACARM  

Postoperative Pulmonary Complications Clinical Trial

Official title:
Effect of IntraoperatiVe High Positive End-ExpirAtory Pressure (PEEP) With ReCruitment MAneuveRs vs Low PEEP on Major Postoperative Pulmonary Complications and Death After On-pump Cardiac Surgery in High-risk Patients: the VACARM Study

Clinical Trial Summary

Controversies remain concerning the best intraoperative mechanical ventilation regimen for major cardiac surgery. While the use of intra operative low tidal volumes is now standard practice, the optimal level of positive end-expiratory pressure (PEEP) and the use of recruitment maneuvers (RM) remain controversial. The aim of this study is to compare two regimens of intraoperative mechanical ventilation on postoperative outcomes in cardiac surgery patients at risk of postoperative pulmonary complications

Clinical Trial Description

In this randomized controlled trial, cardiac surgery patients at risk of postoperative pulmonary complications will be assigned to intraoperative ventilation with high PEEP and RM or intraoperative mechanical ventilation with low PEEP and without RM. The primary endpoint will be a composite endpoint including major postoperative complications within the first postoperative week and death within the 28 days after surgery ;

Study Design

Related Conditions & MeSH terms

  • Postoperative Pulmonary Complications
Clinical Trial Details
NCT number NCT04408495
Study type Interventional
Source Rennes University Hospital
Contact Nathalie DEMAURE
Phone 299284321
Email nathalie.demaure@chu-rennes.fr
Status Recruiting
Phase N/A
Start date July 8, 2021
Completion date July 8, 2026
View Details
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