Clinical Trials Logo
  1. Home
  2. Other
  3. NCT04408495

Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients — VACARM  

Postoperative Pulmonary Complications Clinical Trial

Official title:
Effect of IntraoperatiVe High Positive End-ExpirAtory Pressure (PEEP) With ReCruitment MAneuveRs vs Low PEEP on Major Postoperative Pulmonary Complications and Death After On-pump Cardiac Surgery in High-risk Patients: the VACARM Study

Clinical Trial Summary

Controversies remain concerning the best intraoperative mechanical ventilation regimen for major cardiac surgery. While the use of intra operative low tidal volumes is now standard practice, the optimal level of positive end-expiratory pressure (PEEP) and the use of recruitment maneuvers (RM) remain controversial. The aim of this study is to compare two regimens of intraoperative mechanical ventilation on postoperative outcomes in cardiac surgery patients at risk of postoperative pulmonary complications

Clinical Trial Description

In this randomized controlled trial, cardiac surgery patients at risk of postoperative pulmonary complications will be assigned to intraoperative ventilation with high PEEP and RM or intraoperative mechanical ventilation with low PEEP and without RM. The primary endpoint will be a composite endpoint including major postoperative complications within the first postoperative week and death within the 28 days after surgery ;

Study Design

Related Conditions & MeSH terms

  • Postoperative Pulmonary Complications
Clinical Trial Details
NCT number NCT04408495
Study type Interventional
Source Rennes University Hospital
Contact Nathalie DEMAURE
Phone 299284321
Email nathalie.demaure@chu-rennes.fr
Status Recruiting
Phase N/A
Start date July 8, 2021
Completion date July 8, 2026
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06021249 - Comparing Innovative and Traditional Ventilation Strategies on Atelectasis and Prognosis in Elderly Patients N/A
Not yet recruiting NCT06023017 - The Effect of Preoperative Prone Position Training on PPCs in Patients Undergoing Laparoscopic Sleeve Gastrectomy N/A
Active, not recruiting NCT06304779 - The Effect of Continuous Intravenous Infusion of Lidocaine on PPCs and Prognosis in Emergency Surgical Patients With IAI N/A
Completed NCT03688724 - Perioperative Diaphragm Point of Care Ultrasound
Not yet recruiting NCT05519657 - Incidence and Risk Factors of PPCs in Elderly Patients Undergoing Robot Assisted Laparoscopic Pelvic Surgery
Recruiting NCT06150079 - Individualized PEEP Titration on Postoperative Pulmonary Complications N/A
Completed NCT04605250 - Respiratory Variability for Respiratory Monitoring During the Postoperative Recovery Period N/A
Not yet recruiting NCT02732574 - Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery N/A
Not yet recruiting NCT05830474 - Effect of Continuous Intra-airway Monitoring Under Visible Double-lumen Bronchial Catheter on Postoperative Complications of Lung Surgery N/A
Completed NCT05401253 - The Association of Different Levels of Physical Activity on Postoperative Pulmonary Complications in Patients Undergoing Thoracoscopic Lung Resection Surgery
Not yet recruiting NCT06304493 - REMINDers for Incentive Spirometry in PACU (REMIND-IS in PACU) N/A
Completed NCT02918877 - Anesthetics to Prevent Lung Injury in Cardiac Surgery Phase 1/Phase 2
Not yet recruiting NCT06396767 - Diaphragmatic Inspiratory Amplitude as a Prognosticator for Postoperative Pulmonary Complications After Cardiac Surgery
Recruiting NCT05515809 - Evaluation of the Effect of Para-sternal Block on Postoperative Respiratory Function After Cardiac Sternotomy Surgery Phase 3
Recruiting NCT05922449 - Using Thoracic Paravertebral Block for Perioperative Lung Preservation During VATS Pulmonary Surgery N/A
Recruiting NCT04108130 - An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study N/A
Not yet recruiting NCT05671939 - Different Algorithm Models to Predict Postoperative Pulmonary Complications in Elderly Patients
Not yet recruiting NCT05671952 - Multi-center Study on Reducing Postoperative Pulmonary Complications in Elderly Patients N/A
Not yet recruiting NCT05701449 - Prevention and Treatment of Perioperative Lung Injury in Elderly Patients
Not yet recruiting NCT05671926 - Different Algorithm Models to Predict Postoperative Pneumonia in Elderly Patients