EFFECT OF ANESTHESİA TECHNIQUES ON POSTOPERATİVE COGNİTİVE DYSFUNCTION FOR MMSE AND NSE LEVEL

Postoperative Cognitive Dysfunction Clinical Trial

Official title:

THE EFFECT OF TOTAL INTRAVENOUS ANESTHESIA AND INHALATION ANESTHESIA TECHNIQUES FOR MINI MENTAL STATE EXAMINATION TEST AND NEURON SPECIFIC ENOLASE LEVEL IN LUMBAR DISK HERNIECTOMY OPERATIONS

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04279132
• Other study ID #: 19/10
• Status: Recruiting
• Start date: March 21, 2020
• Est. completion date: July 21, 2020

Study information

• Verified date: February 2020
• Source: Erzincan University
• Contact: UFUK KUYRUKLUYILDIZ
• Phone: 05325840554
• Email: drufuk2001[@]gmail.com
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The aim of this study is to compare the effects of total intravenous anesthesia and inhalation anesthesia methods on postoperative cognitive dysfunction according to Mini Mental State Examination scores and Neuron Specific Enolase levels in lumbar disc herniectomy operations.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Est. completion date: July 21, 2020
• Est. primary completion date: May 21, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

-Lumbal disc herniectomy operation 18-65 age

Exclusion Criteria:

• Patients before and after the coronary artery bypass graft surgery

• patients in the last trimester of pregnancy

• patients with severe heart failure

• liver failure

• kidney failure

• malignant hyperthermia

• lactating patients

• patients with vision or hearing problems

• patients having difficulty in understanding and speaking Turkish

• Parkinson's and Alzheimer's disease

• alcohol and drug addicts

• morbidly obese patients

• intraoperative hypotension, hypertension and hypoxemia

Related Conditions & MeSH terms

• Cognitive Dysfunction
• MINI MENTAL STATE EXAMINATION TEST
• NEURON SPECIFIC ENOLASE
• Postoperative Cognitive Dysfunction

Intervention

Behavioral:
• POSTOPERATIVE COGNITIVE DYSFUNCTION
NEURON SPECIFIC ENOLASE LEVELS IN LUMBAR DISC HERNIECTOMY WITH GENERAL ANESTHESIA MODALITIES

Locations

Country	Name	City	State
Turkey	Erzincan Byu	Erzincan

Sponsors (1)

Lead Sponsor	Collaborator
Erzincan University

Country where clinical trial is conducted

Turkey, 

References & Publications (3)

Baysalman HB, Oguz G, Açikgöz G, Aksakal FN, Ünver SJJotTA, Dergisi ICS-JTAvR. Total Intravenöz ve Desfluran Anestezilerinin Erken Derlenme ve Kognitif Fonksiyonlara Etkileri. 2011;39(1).

Goswami U, Babbar S, Tiwari S. Comparative evaluation of the effects of propofol and sevoflurane on cognitive function and memory in patients undergoing laparoscopic cholecystectomy: A randomised prospective study. Indian J Anaesth. 2015 Mar;59(3):150-5. — View Citation

Luescher T, Mueller J, Isenschmid C, Kalt J, Rasiah R, Tondorf T, Gamp M, Becker C, Sutter R, Tisljar K, Schuetz P, Marsch S, Hunziker S. Neuron-specific enolase (NSE) improves clinical risk scores for prediction of neurological outcome and death in cardi — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	MINI MENTAL STATE EXAMINATION TEST	BELOW 27 SCORE IS ASSOSIATED WITH POSTOPERATIVE COGNITIVE DYSFUNCTION	1 MONTH