Transcranial Magnetic Stimulation Clinical Trial
Official title:
Repetitive Transcranial Magnetic Stimulation as a Potential Tool to Reduce Sexual Arousal
Hyper- and hyposexuality occur frequently in a variety of psychiatric disorders and are
difficult to treat. While there is meta-analytic evidence for the significant effect of
non-invasive brain stimulation on drug and food craving, no study has investigated the
potential of this technique to modulate sexual behavior. The efficacy of a single session of
high-frequency repetitive transcranial magnetic stimulation (rTMS) over the left or right
dorsolateral prefrontal cortex (DLPFC) to reduce sexual arousal was tested against a sham
stimulation.
To test this hypothesis, we employed a randomized, double-blind, sham-controlled crossover
study design. Nineteen healthy male participants received high-frequency rTMS over the left
DLPFC, high-frequency rTMS over the right DLPFC and sham rTMS (each 10 Hz; 110% resting motor
threshold; 60 trains with 50 pulses) in randomized and counterbalanced order with a one-week
interval between stimulation sessions to avoid carryover effects. Participants were exposed
to neutral and sexual cues before and after each intervention and rated their sexual arousal
after each block of cue presentation.
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