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ATG in HLA-matched Sibling HSCT as GVHD Prophylaxis

Hematopoietic Stem Cell Transplantation Clinical Trial

Official title:
ATG Used in Allogeneic Hematopoietic Stem Cell Transplantation From HLA-matched Sibling Donor as GVHD Prophylaxis

Clinical Trial Summary

The protocols including ciclosporin A （CsA）+methotrexate (MTX) +mycophenolate Mofetil(MMF) have been widely used for graft-versus-host disease (GVHD) prophylaxis in allogeneic hematopoietic stem cell transplantation from HLA-matched sibling donor (MSD). Nevertheless, severe chronic graft-versus-host disease (cGVHD) remains an obstacle for MSD HSCT. A growing body of studies have suggested antithymocyte globulin (ATG) could reduce the incidence of cGVHD. This study is aim to evaluate the efficacy of a protocol that includes CsA, MTX, MMF and ATG in recipients of MSD HSCT.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Hematopoietic Stem Cell Transplantation
Clinical Trial Details
NCT number NCT04203108
Study type Interventional
Source Nanfang Hospital of Southern Medical University
Contact Ren Lin, MD
Phone +86-020-62787883
Email lansinglinren@hotmail.com
Status Recruiting
Phase Phase 4
Start date September 1, 2019
Completion date December 31, 2022
View Details
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