Posture Training and Cerebellar Stimulation in Elderly People

Transcranial Electrical Stimulation Clinical Trial

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Official title:

Enhancement of Posture Training Effectiveness With Error-enhancing Feedback and Cerebellar Stimulation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04154397
• Other study ID #: MOST 105-2314-B-006 -014 -MY3
• Status: Completed
• Phase: N/A
• Start date: May 20, 2015
• Est. completion date: September 30, 2019

Study information

• Verified date: October 2019
• Source: National Cheng-Kung University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Motor learning relies on both feedback and feedforward mechanisms to keep progressive optimization of motor behaviors in a coordinated manner. Error correction based on the fronto-parietal loop is subject to error information inherent within visual feedback. On the other hand, cerebellar activity for restoration of efferent copy involves in operation of feedforward mechanism. Therefore, the amount of error feedback and excitation of cerebellum are keyed to effectiveness of motor learning. Although postural training is of empirical value to prevent falling from the elderly, yet none of previous studies have ever been devoted to improve effectiveness of postural training via manipulations of visual error feedback and cerebellar stimulation.

From the aspect of cognition-motor interaction, the present proposal is a three-year project intended to promote effectiveness of postural training for the elderly. In the first year, feedback-based training benefits from a dynamic postural task under the conditions of different visual size of error feedback (error-reducing feedback, error-enhancing feedback, and fixed error feedback) will be contrasted. In the second year, feedforward-based training benefits from a dynamic postural task by application of cerebellum transcranial electrical stimulation (ctDCS) of different modes (direct current vs. noise vs. sham) will be contrasted. In the third year, the proposal will examine whether postural training with combined approach (error-enhancing feedback and ctDCS) could result in a superior training benefit to those of error-enhancing feedback alone and ctDCS alone approaches. In addition to innovative training intervention, this proposal will make use of current non-linear analyses on EEG signals and postural sway with graph analysis and heading analysis, respectively. It is expected to gain additional insight into behavior and brain mechanisms underlying learning-related changes with the postural training, potentially lending to a more effective training paradigm for postural stability of the elderly.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: September 30, 2019
• Est. primary completion date: January 24, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Age above 60 years old healthy older adults without a history of falls.

• Able to understand and give informed consent.

• The Mini-Mental State Examination test score above 25-30.

• Lower limb muscle strength is evaluated as G grade

• The corrected visual acuity was within the normal range.

Exclusion Criteria:

• Any known history of mental illness

• Any neuromuscular or degenerative neurological disease(ex:stroke?SCI?TBI...etc)

• Any known history of cerebral cerebellar disease or intracranial metal implants.

• Weak of hearing or wearing a hearing aid

Related Conditions & MeSH terms

• Transcranial Electrical Stimulation

Intervention

Device:
• cerebellar transcranial stimulation
Feedforward-based training benefits from a dynamic postural task by application of cerebellum transcranial electrical stimulation (ctDCS) of different modes (direct current vs. noise vs. sham) were administered using a one-channel direct current stimulator (NeuroConn DC-Stimulator PlusTM) with study mode enabled for single blinding. Following the baseline trial of posture tracking, participants of three groups were seated in a chair for 20 min to receive either active or sham cerebellar tDCS prior to the posture tracking and transfer test phases.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
National Cheng-Kung University Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Graph theoretical analysis of EEG functional network	Graph theory will characterize EEG functional connectivity and brain network efficiency regarding to brain mechanisms for practice-related leaning transfer.This project introduced EEG pattern analysis into the posture research project. It is expected to find out the changes in brain network efficiency and functional structure caused by posture training. It is a tool for understanding the neural mechanism of this project.	through study completion, an average of 1 year
Secondary	heading analysis of center of pressure	Trajectories of central of pressure will be analyzed with stabilogram diffusion analysis to reveal behavior mechanisms for practice-related variations in feedback and feedforward process for error corrections.	through study completion, an average of 1 year