Clinical Trials Logo
  1. Home
  2. Other
  3. NCT04139018

Timolol Gel for Epistaxis in Hereditary Hemorrhagic Telangiectasia — ETIC-HHT  

Hereditary Hemorrhagic Telangiectasia Clinical Trial

Official title:
Efficacy of a Timolol Gel in the Care for Epistaxis in Patients With Hereditary Hemorrhagic Telangiectasia: A Double-Blinded, Randomized Controlled Trial

Clinical Trial Summary

This study is a double-blinded, randomized controlled trial to evaluate the efficacy of an intranasal topical timolol gel in the care for epistaxis in adults with hereditary hemorrhagic telangiectasia.

Clinical Trial Description

This study is a double-blinded, placebo-controlled, 8-week randomized clinical trial investigating the efficacy of timolol gel in the management of epistaxis in adults with HHT. The Specific Aims are to determine in adults with HHT-associated epistaxis: 1. If topical timolol gel is more effective than placebo in reducing the frequency and severity of epistaxis. 2. If topical timolol gel is more effective than placebo in improving hemoglobin levels. 3. The frequency of adverse events, side effects, and safety profile of topical timolol gel delivered to the nasal mucosa. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04139018
Study type Interventional
Source Washington University School of Medicine
Contact
Status Completed
Phase Phase 2
Start date October 20, 2019
Completion date May 20, 2020
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT02874326 - Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber Phase 2
Completed NCT00389935 - Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Phase 2
Active, not recruiting NCT04646356 - Tacrolimus Trial for Hereditary Hemorrhagic Telangiectasia (HHT) Phase 2
Completed NCT03691142 - Evaluation of Obstetrical and Neonatal Complications in Hereditary Haemorrhagic Telangiectasia (HHT)
Recruiting NCT04404881 - Bevacizumab In Hereditary Hemorrhagic Telangiectasia Phase 2
Completed NCT02977637 - MRA With Feraheme in HHT Phase 1
Completed NCT01485224 - Efficacy of Thalidomide in the Treatment of Hereditary Hemorrhagic Telangiectasia Phase 2
Recruiting NCT06259292 - Comprehensive HHT Outcomes Registry of the United States (CHORUS)
Active, not recruiting NCT04150822 - Hereditary Hemorrhagic Telangiectasia (HHT) Research Outcomes Registry
Recruiting NCT03850964 - Effects of Pazopanib on Hereditary Hemorrhagic Telangiectasia Related Epistaxis and Anemia (Paz) Phase 2/Phase 3
Completed NCT05752253 - Counseling Intervention in Hereditary Hemorrhagic Telangiectasia in the COVID Era. N/A
Not yet recruiting NCT02458703 - Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs With and Without Airflow Obstruction N/A
Completed NCT01752049 - Topical Anti-angiogenic Therapy for Telangiectasia in HHT: Proof of Concept Phase 1/Phase 2
Completed NCT00004649 - Study of the Natural History and Genotype-Phenotype Correlations of Hereditary Hemorrhagic Telangiectasia Patients N/A
Active, not recruiting NCT04874558 - Ultra-low-dose Chest CT for HHT
Completed NCT01031992 - Tranexamic Acid and Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Phase 3
Recruiting NCT05269849 - Sirolimus for Nosebleeds in HHT Phase 2
Completed NCT03572556 - Prospective Descriptive Study of the Angiogenic T Cell Population in Subjects With Hereditary Hemorrhagic Telangiectasia (HHT)
Completed NCT04113187 - Propranolol for Epistaxis in Hereditary Hemorrhagic Telangiectasia Patients Phase 3
Not yet recruiting NCT02963129 - Treatment of Nasal Staphylococcus Aureus Colonization in Patients With HHT Phase 3