Neuromyelitis Optica Spectrum Disorders Clinical Trial
Official title:
Treatment Response Among Chinese Patients With Acute Attack of Neuromyelitis Optica Spectrum Disorders: A Prospective, Multicenter Real-world Study
Neuromyelitis Optica (NMO)/ Neuromyelitis Optica Spectrum Disorders (NMOSD) is an
immune-mediated inflammatory demyelinating disease of the central nervous system mainly
involving optic nerve and spinal cord. It is clinically characterized by simultaneous or
sequential involvement of the optic nerve and spinal cord, presenting a progressive or
remission and relapse course, which can lead to paralysis and blindness.
The objective of this study is to provide evidence regarding treat effects and factors
related to prognosis which will help physicians better evaluable risk-benefit in NMOSD
management and improve patients' outcome.
Neuromyelitis Optica (NMO)/ Neuromyelitis Optica Spectrum Disorders (NMOSD) is an
immune-mediated inflammatory demyelinating disease of the central nervous system mainly
involving optic nerve and spinal cord. It is clinically characterized by simultaneous or
sequential involvement of the optic nerve and spinal cord, presenting a progressive or
remission and relapse course, which can lead to paralysis and blindness.
Globally, there is no solid data available for the diagnosis, treatment and prognosis of
patients with acute Neuromyelitis Optica Spectrum Disorders (NMOSD) attack, particularly very
rare data from prospective studies. This is a multicenter, prospective, real-world cohort
study in patients with acute NMOSD attack in China.
Baseline data for approximately 200 patients with acute NMOSD attack from approximately 4
centers will be collected. Patients with acute NMOSD attack (including first episodes and
relapses) whose expansile disability status score (EDSS ) ≥ 2 points at baseline will be
eligible to be further included in prospective study cohort for analysis of treatment effects
and prognosis.
The objective of this study is to provide evidence regarding treat effects and factors
related to prognosis which will help physicians better evaluable risk-benefit in NMOSD
management and improve patients' outcome.
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