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Defining a Dosing Regimen With Maximal Absorption for Oral Iron Supplementation During Pregnancy

Iron Deficiency Anemia of Pregnancy Clinical Trial

Official title:
Optimizing Oral Iron Supplementation Regimens During Pregnancy Using Serum Hepcidin Profiles and Iron Stable Isotopes: Defining a Dosing Regimen With Maximal Absorption and Minimal Gastrointestinal Side Effects

Clinical Trial Summary

Iron deficiency anemia (IDA) is common during pregnancy and has adverse effects on the mother, fetus and newborn. Oral iron supplements are usually recommended to prevent ID/IDA during pregnancy.

The aim of this study is to define an iron supplementation schedule with maximal absorption using serum hepcidin profiles and stable iron isotopes in pregnant women. In this randomized, open-label trial, fractional and total iron absorption will be compared from daily dosing with 60 mg iron versus alternate day and every third day dosing with 120 mg iron in pregnant Thai women with low iron stores (n=28) during their second trimester of pregnancy.

This study could have wide impact, providing the evidence base for revised, improved recommendations for iron supplementation during pregnancy.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04074707
Study type Interventional
Source Swiss Federal Institute of Technology
Contact Hanna von Siebenthal
Phone +41 44 632 53 73
Email hanna.vonsiebenthal@hest.ethz.ch
Status Not yet recruiting
Phase N/A
Start date September 2019
Completion date December 2019
View Details
See also
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Available NCT05151679 - Chelated Oral Iron Versus Intravenous Iron Sucrose for Treatment of Iron Deficiency Anemia Late in Pregnancy