VAP - Ventilator Associated Pneumonia Clinical Trial
Official title:
The Effectiveness of the Modified Bundle in the Prevention of Ventilator-associated Pneumonia in Adult Patients in the Intensive Care Unit.
Ventilator-associated pneumonia (VAP) is an important cause of prolonged intensive care unit
and hospital length of stay, healthcare costs and mortality in mechanically ventilated
patients. There are an international guidelines for VAP diagnosis, treatment and prevention
(Infectious Diseases Society of America(IDSA)/American Thoracic Society (ATS) 2016 and
European Respiratory Society (ERS) / European Society of Intensive Care Medicine (ESICM) /
European Society of Clinical Microbiology and Infectiuos Diseases (ESCMID) / Asociacion
Latinoamericana del Torax (ALAT) 2017) routinely used in most ICUs. The investigator planed
on comparing two strategies for prevention of VAP in mechanically ventilated patients: the
routine VAP bundle ( historical group - VAP1) and the modified VAP bundle ( study group -
VAP2) by using 3 modifications ( Shiley Evac Endotracheal tube with TaperGuard Cuff,
Automatic continuous subglottic secretion drainage (SSD) and continuous tube cuff pressure
monitoring).
The aim of the study is an assessment of the effectiveness of the modified prevention of VAP
in reduction of: early and late VAP cases, mechanical ventilation days (MV), length of stay
(LOS) in the ICU, 28 day mortality and multi drug resistent pathogens (MDR) cases in adult
ICU patients.
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