Intraventricular Hemorrhage, Endoscopic Intraventricular Evacuation Surgery, Extraventricular Drainage Clinical Trial
Official title:
Endoscopic Intraventricular Hematoma Evacuation Surgery Versus External Ventricular Drainage for the Treatment of Patients With Moderate to Severe Intraventricular Hemorrhage: a Multicenter, Randomized, Controlled Trial
Intraventricular hemorrhage (IVH) accounts for about 20% of intracerebral hemorrhage, but its mortality rate is as high as 50%-80%. External ventricular drainage (EVD) can rapidly reduce intracranial pressure, but clinical practice found that drainage catheters are often blocked by blood clots and long-term thrombolytic therapy is likely to cause secondary bleeding. The application of neuroendoscopy in IVH has attracted more and more attention in recent years. Studies have shown that the use of neuroendoscopy for IVH evacuation (with EVD) has advantages over EVD alone. However, the cases of most current research are small and all of them are retrospective studies, which means lacking prospective clinical studies to provide high-quality evidence. Based on this, we intend to conduct a randomized, controlled, multi-center clinical trial to compare the prognosis of patients who undergo endoscopic IVH evacuation surgery versus those who undergo external ventricular drainage for moderate to severe IVH.
Spontaneous Intraventricular hemorrhage (IVH) is defined as bleeding into the cerebral
ventricular system caused by spontaneous rupture of brain arteries, veins and capillaries
instead of trauma. IVH accounts for about 20% of cerebral hemorrhage, but its mortality rate
is as high as 50%-80%. According to the results of the STICH trial, the prognosis of patients
with IVH is worse than that of patients without IVH (p<0.00001); if patients with IVH have
hydrocephalus, the prognosis is the worst.
According to the edition of 2015 Chinese multidisciplinary experts' consensus for spontaneous
cerebral hemorrhage diagnosis and treatment and 2015 AHA/ASA spontaneous cerebral hemorrhage
diagnosis and treatment guidelines, for patients with small amount of IVH without obstructive
hydrocephalus, conservative treatment or continuous lumbar drainage can be effective. For
patients with large amount of IVH (hematoma occupying more than 50% of the lateral ventricle,
secondary obstructive hydrocephalus or obviously increased intracranial pressure), the
occupancy effect is dramatic and patients are prone to suffering from hydrocephalus and
cerebral palsy, in which circumstances urgent evacuation of hematoma is required, but it is
controversial whether it is beneficial for the patients and whether it can improve the
prognosis of patients.
As the regular treatment for IVH, external ventricular drainage (EVD) can rapidly reduce
intracranial pressure, but clinical practice found that drainage catheters are often blocked
by blood clots, and long-term thrombolytic therapy is likely to cause secondary bleeding.
Usually, the catheters need to be removed or replaced one week after placement as for the
increasing risk of infection.
The application of endoscopy in IVH has attracted more and more attention. Studies have shown
that the use of endoscopy for IVH evacuation (with EVD) has advantages over EVD alone. The
incidence of postoperative hydrocephalus and the need for ventricular-peritoneal shunt
surgery is lower. However, the cases of most current research are small and all of them are
retrospective studies. There are no such clinical trials registered at home and abroad, and
that is, there is a lack of prospective high-quality clinical studies to further demonstrate
the effect of endoscopic treatment for IVH.
Based on this, we intend to conduct a randomized, controlled, multi-center clinical trial to
compare the prognosis of patients who undergo endoscopic IVH evacuation surgery versus those
who undergo external ventricular drainage for moderate to severe IVH.
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