Neonatal Respiratory Distress Syndrome Clinical Trial
Official title:
Impact of Neurophysiological Facilitation of Respiration in Preterm Neonates Admitted in Level II Neonatal Intensive Care Unit: A Randomized Controlled Trail
Background: Respiratory distress syndrome (RDS) or Neonatal respiratory distress syndrome
(NRDS) is characterized by pulmonary insufficiency, in preterm neonates and is the major
cause of death in preterm. Neurophysiological facilitation of Respiration (NFR) technique
produce reflex respiratory movement response, as it involves application of external
proprioceptive and tactile stimuli that is known to alter the rate and depth of breathing
Aim: This study is being conducted to determine the effectiveness of NFR in preterm neonates
diagnosed with RDS.
Methods: In this study 30 preterm (1- 8 days) neonates diagnosed with Respiratory Distress
Syndrome will be taken and assigned into two groups,Experimental group (n=15) and control
group (n=15). Neonates within eight days of birth those born before 37 weeks of gestation,
diagnosed with RDS were included in the study. Neonate undergone recent surgery or congenital
disorder, or medically unstable will be excluded.
Data analysis: Normality of the collected data will be analyzed with either two of the
normality test i.e. Shapiro Wilk test and Kolmogorov Smirnov test based on sample size.
Demographics characteristic of collected sample will be expressed in a mean standard
deviation or median and range based normality. For Between group comparison Independent t
test or Mann Whitney U test and for within group comparison paired t test or Wilcoxon singed
ranked test will be used.
1. Introduction:
Respiratory distress syndrome (RDS) or Neonatal respiratory distress syndrome (NRDS) is
characterized by pulmonary insufficiency, in preterm neonates and is the major cause of
death in preterm. The major cause of RDS is surfactant deficiency. Main features of
respiratory distress syndrome are retraction, grunting and tachypnoea and sometimes
cyanosis is also present as an associated sign.There are various types of Physiotherapy
Interventions given for respiratory disorders in neonates, namely they are chest
percussion, vibration and shaking, postural drainage (gravity assisted),
Neurophysiological Facilitation of Respiration (NFR). NFR technique produce reflex
respiratory movement response, as it involves application of external proprioceptive and
tactile stimuli that is known to alter the rate and depth of breathing.
1.1Problem statement: Role of pulmonary NFR has shown to be effective in adult patients
with COPD and in geriatric population. This study aims to evaluate the effectiveness of
NFR in neonates with respiratory conditions.
1.2 Objective of the study: To demonstrate the benefit of NFR in hospitalised neonates
with Respiratory Distress Syndrome (RDS).
2. Procedure:
Participants will be selected by simple random sampling method according to the selection
criteria.Procedure will be explained to the patient and written consent will be taken from
them.
Outcome measures will be taken on the first day prior to the intervention and on the 5th day
after the intervention. Outcome measure used will be Respiratory Rate, Heart Rate, Saturation
of Peripheral Oxygen (SPO2) and chest expansion to see the improvement in the patient.
Interventions - In experimental group - PNF respiration will be given to the neonate in
supine position.
In control group - No intervention will be given in control group. Outcome measure will be
measured at baseline after 5 days.
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