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Clinical Trial Summary

This phase 2 study is designed to evaluate the safety, tolerability and efficacy of allogeneic donor lymphocyte infusions (DLI) combined with the bispecific T cell engager blinatumomab in B-precursor ALL patients who have mixed chimerism (MC) or are MRD-positive after allogeneic SCT and are refractory to at least one MRD- or MC-targeted therapy (i.e. blinatumomab, DLI, tyrosine kinase inhibitors or other agents).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Acute Lymphoblastic Leukemia
  • Acute Lymphoblastic Leukemia in Remission
  • Acute Lymphoblastic Leukemia, Adult
  • B Cell Precursor Acute Lymphoblastic Leukemia With Mixed Chimerism or Minimal Residual Disease After Allogeneic Stem Cell Transplantation
  • B-Cell Acute Lymphoblastic Leukemia
  • Leukemia
  • Leukemia, Lymphoid
  • Neoplasm, Residual
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT number NCT03982992
Study type Interventional
Source Ludwig-Maximilians - University of Munich
Contact
Status Withdrawn
Phase Phase 2
Start date June 1, 2019
Completion date November 30, 2021

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