Clinical Trials Logo

Clinical Trial Summary

The aim of this study is to evaluate the effect of the addition of epinephrine to bilateral real time ultrasound guided pterygopalatine ganglion blocks on intra-operative bleeding and blood loss during functional endoscopic sinus surgery (FESS).


Clinical Trial Description

FESS is the treatment of choice in patients with medically refractory chronic rhinosinusitis and chronic polypous rhinosinusitis. This surgery relies on minimal surgical site bleeding to be performed efficiently and safely. Hemorrhage during FESS decreases visibility of the surgical field and this increases the risk of vascular, orbital and intracranial complications as well as procedural failure. Thus the importance of minimizing surgical bleeding in this procedure. The maxillary artery is the primary blood supply for the sinuses and midface. Conceptually the application of epinephrine into the pterygopalatine fossa onto the maxillary artery with the block should result in constriction of this artery and subsequently, less bleeding from the surgical site. This randomized, double-blinded, controlled pilot study will investigate the utility of addition of epinephrine to bilateral pterygopalatine ganglion blocks performed under ultrasound guidance in minimizing surgical site bleeding and overall blood loss and the potential for shortening the surgical time. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03970655
Study type Interventional
Source University of Florida
Contact Cameron R Smith, MD
Phone 352-273-8651
Email csmith@anest.ufl.edu
Status Recruiting
Phase Phase 1/Phase 2
Start date September 25, 2019
Completion date December 15, 2026

See also
  Status Clinical Trial Phase
Recruiting NCT05895929 - The Role of IL5 in Epithelial Cell Integrity Early Phase 1
Completed NCT03673956 - Topical Antibiotics in Chronic Rhinosinusitis Phase 1/Phase 2
Not yet recruiting NCT04514120 - Alsaleh-Javer Endoscopic Sinus Score (AJESS) System N/A
Recruiting NCT03963648 - NO Measurements in Screening for Asthma and OSA, in Patients With CRSwNP N/A
Recruiting NCT05009758 - Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Patients With or Without Nasal Polyps N/A
Active, not recruiting NCT05553951 - Adherence in Global Airways N/A
Completed NCT03563521 - Identifying Serum Cytokine Profiles of Distinct Inflammatory Phenotypes in Severe Asthma
Completed NCT05035654 - LYR-220 for Adult Subjects With Chronic Rhinosinusitis (BEACON Study) Phase 2
Withdrawn NCT03369574 - Study of Chronic Rhinosinusitis Symptoms in Asthma Patients Undergoing Treatment With Reslizumab
Recruiting NCT05400616 - Nasal Microbiota Transfer Therapy in Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) N/A
Recruiting NCT04628442 - Tissue Immune Interaction in Nasal Polyposis
Completed NCT04041609 - LYR-210 Depot (LYR-210) for Adult Subjects With Chronic Sinusitis (LANTERN Study) Phase 2
Completed NCT04048070 - The Effect of Enhanced Recovery After Surgery in Endoscopic Sinus Surgery N/A
Recruiting NCT03439865 - Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis Early Phase 1
Recruiting NCT05857228 - Viral and Epigenetic Influences in CRSwNP
Completed NCT03122795 - Sinonasal Microbiome Transplant as a Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP) N/A
Recruiting NCT05295459 - Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2) Phase 3
Completed NCT04858802 - A Clinical Evaluation of PROPEL® Contour Sinus Implant N/A
Completed NCT04572516 - Botulium Toxin Type A In Non Infectious Chronic Rhinosinusitis Phase 3
Completed NCT04595461 - Effect of Patient Education Videos on Perioperative Anxiety in Patients Undergoing Endoscopic Sinus Surgery N/A