Functional Magnetic Resonance Imaging Clinical Trial
Official title:
Assessment of Brain Activity During Complex Fine Hand Movements: an fMRI Study
Verified date | July 2020 |
Source | Akdeniz University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Brain cortex controls movement but the influence of peripheral component of movement on the
cortex is not known. Functional Magnetic Resonance Imaging(fMRI) studies in stroke and fantom
limb patients investigate cortex areas activated during execution and imagination of complex
hand movements. These studies aim to understand the mechanisms of the motor component of
movement but the results are limited as there is no effector organ in fantom limb patients
and the affecting organ is damaged in stroke patients. The investigators hypothesized that
the areas of the cortex that is activated to remember, set-up and order to move can be
isolated from the areas that are activated during the motor component of movement. To prove
this hypothesis the investigators developed a model that investigate the brain activation
areas during the patient try to execute and imagine doing a complex motor task (sequential
opposition with the thumb to the other four fingers) with a peripherally blocked arm. Brain
fMRI in 15 right-handed patients scheduled to undergo right-hand surgery with peripheral
block anesthesia will be obtained before the surgery day and just before surgery after the
block. Participants will be screened when executing the task (after the block they just
attempt), during rest and during they imagine doing the task. Bilateral cortex activation
areas will be compared when the right hand was intact and was peripherally blocked.
There are many unknowns in the relationship between the brain-peripheric organ during
movement. The investigators hope that some of these mechanisms will be identified by the new
model we used in our study. The final benefit will be to develop stroke therapies and new
therapies for neuropathic pain which is closely related to motor function.
Status | Completed |
Enrollment | 15 |
Est. completion date | April 12, 2020 |
Est. primary completion date | January 12, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion criteria: Patients - >18 years - have right-hand surgery with peripheral blockage of the arm - who give written informed consent - who are right-hand dominant Exclusion criteria: Patients - who do not give written informed consents, - use their left hand dominantly, - have a neurologic or psychiatric disease, - have hearing and visual loss, - have a history of substance abuse - have surgery in the previous 12 months, - have major systemic disease(ASA III and IV), - have history of drugs that alter neurologic activity, - are unable to stay at MR machine without sedation, - with an expected surgery duration of more than 3 hours, - have a motor deficit at their right hand that makes the performance of the motor task impossible |
Country | Name | City | State |
---|---|---|---|
Turkey | AkdenizU | Antalya |
Lead Sponsor | Collaborator |
---|---|
Akdeniz University |
Turkey,
Le Bihan D, Karni A. Applications of magnetic resonance imaging to the study of human brain function. Curr Opin Neurobiol. 1995 Apr;5(2):231-7. Review. — View Citation
Osumi M, Sumitani M, Wake N, Sano Y, Ichinose A, Kumagaya S, Kuniyoshi Y, Morioka S. Structured movement representations of a phantom limb associated with phantom limb pain. Neurosci Lett. 2015 Sep 25;605:7-11. doi: 10.1016/j.neulet.2015.08.009. Epub 2015 Aug 10. — View Citation
Ruffino C, Papaxanthis C, Lebon F. Neural plasticity during motor learning with motor imagery practice: Review and perspectives. Neuroscience. 2017 Jan 26;341:61-78. doi: 10.1016/j.neuroscience.2016.11.023. Epub 2016 Nov 25. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Compare the area of brain activation during the participant try to perform a motor task when the hand is blocked with area of brain activation when the hand actually perform the task by using fMRI | complex hand movement: sequential repetitive thumb to other four digit opposition with the right hand | 1 year | |
Primary | Comparing brain activation areas while the participant imagine to perform a motor task when the hand is blocked with brain activation areas when the hand is intact, by fMRI | complex hand movement: sequential repetitive thumb to other four digit opposition with the right hand | 1 year | |
Secondary | Comparing the area of ipsilateral cortex brain activity when the participant is intending to perform the complex motor task with the area while imagining doing the complex motor task when the arm is blocked by anesthesia. | complex hand movement: sequential repetitive thumb to other four digit opposition with the right hand | 1 year |
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