Cognitive Rehabilitation in Older Adults With Neuron-up (CROAN)

Indication for Modification of Patient Cognitive Status Clinical Trial

Official title:

Effectiveness of Two Predefined Groups With Cognitive Rehabilitation in Older Adults With the Program Neuron-up

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03944135
• Other study ID #: UBurgos
• Secondary ID: IR 10/2019
• Status: Completed
• Phase: N/A
• Start date: February 15, 2019
• Est. completion date: February 20, 2019

Study information

• Verified date: May 2019
• Source: Universidad de Burgos
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Introduction. The application of new technologies for cognitive rehabilitation has increased over the last years and has enabled occupational therapists to work more efficiently, minimizing costs and time for analysis, management, and design of activities.

Objective. The purpose of the present study was to assess the effect of cognitive intervention using the web platform Neuronup in a group of elderly subjects; the study is based on the dependent variables (memory, attention, and language) analyzed with the abbreviated Barcelona Test.

Subjects and Methods. Aquasi-experimental design was carried out with subjects assigned to two groups: a control group (20 subjects) and an experimental group (20 subjects). The abbreviated Barcelona Test was administered to assess patients before and after the intervention with this software to draw conclusions.

Description:

Introduction. The application of new technologies for cognitive rehabilitation has increased over the last years and has enabled occupational therapists to work more efficiently, minimizing costs and time for analysis, management, and design of activities.

Objective. The purpose of the present study was to assess the effect of cognitive intervention using the web platform Neuronup in a group of elderly subjects; the study is based on the dependent variables (memory, attention, and language) analyzed with the abbreviated Barcelona Test.

Subjects and Methods. Aquasi-experimental design was carried out with subjects assigned to two groups: a control group (20 subjects) and an experimental group (20 subjects). The abbreviated Barcelona Test was administered to assess patients before and after the intervention with this software to draw conclusions.

Results. Analyses of variance (ANOVA), analyses of covariance (ANCOVA), and multivariate analyses of variance (MANOVA) were perfomed in the memory, orientation, reading, and language domains. Statistically signifcant differences were recorded in all domains except language where scores remained the same.

Conclusion. It has been demonstrated that Neuronup is an effective program for improving cognitive processes such as memory, attention, and orientation in older adults, hence it would be beneficial to implement technology-based treatments conducted by specialized professionals.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: February 20, 2019
• Est. primary completion date: February 20, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 75 Years to 85 Years

Eligibility

Inclusion Criteria:

1. subjects between 75 and 85 years of age;

2. obtain a score greater than 20 points for the MEC (Lobo's cognitive mini-exam); and

3. attend occupational therapy sessions on a regular basis.

Exclusion Criteria:

1. presence of neurocognitive disorder (Alzheimer's-type dementia among others);

2. not be an institutionalized resident at a nursing home;

3. a family history of a psychiatric problem;

4. presence of polipathology; and

5. have lived at a nursing home for less than 2 months.

Related Conditions & MeSH terms

• Indication for Modification of Patient Cognitive Status

Intervention

Other:
• Web platform: Neuronup
Neuronup is a web platform designed for neuropsychological rehabilitation that is focused on functional cognitive impairments resulting from normal aging and other causes. Neuronup emerged as a scientific, viable and accessible technological initiative.

Locations

Country	Name	City	State
Spain	Olalla Saiz Vazquez	Burgos

Sponsors (1)

Lead Sponsor	Collaborator
Universidad de Burgos

Country where clinical trial is conducted

Spain, 

References & Publications (14)

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Jean L, Bergeron ME, Thivierge S, Simard M. Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature. Am J Geriatr Psychiatry. 2010 Apr;18(4):281-96. doi: 10.1097/JGP.0b013e3181c37ce9. Review. — View Citation

Lachman ME, Weaver SL, Bandura M, Elliott E, Lewkowicz CJ. Improving memory and control beliefs through cognitive restructuring and self-generated strategies. J Gerontol. 1992 Sep;47(5):P293-9. — View Citation

Mohs RC, Ashman TA, Jantzen K, Albert M, Brandt J, Gordon B, Rasmusson X, Grossman M, Jacobs D, Stern Y. A study of the efficacy of a comprehensive memory enhancement program in healthy elderly persons. Psychiatry Res. 1998 Feb 27;77(3):183-95. — View Citation

Neely AS, Bäckman L. Effects of multifactorial memory training in old age: generalizability across tasks and individuals. J Gerontol B Psychol Sci Soc Sci. 1995 May;50(3):P134-40. — View Citation

Novoa AM, Juárez O, Nebot M. [Review of the effectiveness of cognitive interventions in preventing cognitive deterioration in healthy elderly individuals]. Gac Sanit. 2008 Sep-Oct;22(5):474-82. Review. Spanish. — View Citation

Rey Cao A, Canales Lacruz I, Táboas Pais MI. [Quality of life perceived by the elderly. Results of the "Memory in movement" program which provide cognitive stimulation using motricity]. Rev Esp Geriatr Gerontol. 2011 Mar-Apr;46(2):74-80. doi: 10.1016/j.re — View Citation

Valdizán JR. [Cognitive functions and neuronal networks in the social brain]. Rev Neurol. 2008;46 Suppl 1:S65-8. Review. Spanish. — View Citation

Valencia C, López-Alzate E, Tirado V, Zea-Herrera MD, Lopera F, Rupprecht R, Oswald WD. [Cognitive effects of combined memory and psychomotor training in elderly adults]. Rev Neurol. 2008 Apr 16-30;46(8):465-71. Spanish. — View Citation

Valentijn SA, van Hooren SA, Bosma H, Touw DM, Jolles J, van Boxtel MP, Ponds RW. The effect of two types of memory training on subjective and objective memory performance in healthy individuals aged 55 years and older: a randomized controlled trial. Patient Educ Couns. 2005 Apr;57(1):106-14. — View Citation

Wenisch E, Cantegreil-Kallen I, De Rotrou J, Garrigue P, Moulin F, Batouche F, Richard A, De Sant'Anna M, Rigaud AS. Cognitive stimulation intervention for elders with mild cognitive impairment compared with normal aged subjects: preliminary results. Agin — View Citation

Wilkinson AJ, Yang L. Long-Term Maintenance of Inhibition Training Effects in Older Adults: 1- and 3-Year Follow-Up. J Gerontol B Psychol Sci Soc Sci. 2016 Jul;71(4):622-9. doi: 10.1093/geronb/gbu179. Epub 2015 Jan 7. — View Citation

* Note: There are 14 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reading is assessed in two pre defined groups of individuals	The abbreviated Barcelona Test is used to assess cognitive reading function in which the results highlight the existence of statistically significant differences in the difference scores reading.; The test consists of 41 subtests that generate 55 variables which assess the following cognitive functions: language, orientation, forward/backward digit span, automatized sequences and mental control, repetition, confrontation naming, semantic fluency (animals), verbal comprehension, reading, writing, praxis (ideomotor, melokinetic, and constructional), visual perceptual functions, verbal memory (story), visual memory, arithmetic problems, similarities, digit-symbol and block design. The cognitive profile and global scale score were obtained from all scores.	3 months
Primary	Memory is assessed in two pre defined groups of individuals	The abbreviated Barcelona Test is used to assess cognitive memory function in which the results highlight the existence of statistically significant differences in the difference scores memory.; The test consists of 41 subtests that generate 55 variables which assess the following cognitive functions: language, orientation, forward/backward digit span, automatized sequences and mental control, repetition, confrontation naming, semantic fluency (animals), verbal comprehension, reading, writing, praxis (ideomotor, melokinetic, and constructional), visual perceptual functions, verbal memory (story), visual memory, arithmetic problems, similarities, digit-symbol and block design. The cognitive profile and global scale score were obtained from all scores.	3 months
Primary	Orientation is assessed in two pre defined groups of individuals	The abbreviated Barcelona Test is used to assess cognitive orientation function in which the results highlight the existence of statistically significant differences in the difference scores orientation.; The test consists of 41 subtests that generate 55 variables which assess the following cognitive functions: language, orientation, forward/backward digit span, automatized sequences and mental control, repetition, confrontation naming, semantic fluency (animals), verbal comprehension, reading, writing, praxis (ideomotor, melokinetic, and constructional), visual perceptual functions, verbal memory (story), visual memory, arithmetic problems, similarities, digit-symbol and block design. The cognitive profile and global scale score were obtained from all scores.	3 months