Post-Traumatic Stress Disorder in Old Age Clinical Trial
— I-TSPT-ROfficial title:
Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects
| Verified date | July 2021 |
| Source | Centre Hospitalier de Niort |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested. This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment. The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.
| Status | Completed |
| Enrollment | 20 |
| Est. completion date | March 26, 2021 |
| Est. primary completion date | April 15, 2019 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 65 Years to 85 Years |
| Eligibility | Inclusion Criteria: - Regarding the constitution of the group patient (TSPT-R): - Subjects 65 years of age or older - Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years - The traumatic event must have taken place at the latest before 65 years - Affiliated person or beneficiary of a social security scheme. - Written consent before any examination required by research) Regarding the constitution of the control group: - Subjects 65 years of age or older - No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not) - Affiliated person or beneficiary of a social security scheme. - Written consent before any examination required by the research). Exclusion Criteria: - For both groups: - Acute or chronic cognitive impairment known - GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely: - 22 if no diploma - 23 if certificate of study - 25 if patent - 26 if bin or more - Remove one point at each threshold if age> 80 years - Sensory or motor disorder preventing the passing of different tests - Psychotic disorder - Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11) - Disorder of the use of a moderate or severe substance (except tobacco). - Patients under guardianship or curatorship. |
| Country | Name | City | State |
|---|---|---|---|
| France | Centre Hospitalier de Niort | Niort |
| Lead Sponsor | Collaborator |
|---|---|
| Centre Hospitalier de Niort |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Inhibition score measured by the Think / No-Think Test | the average of the inhibition score measured by the "Think / No-Think" test as defined by Anderson and Green (2001) and then reviewed by Anderson et al. in 2011 | 1 month |