Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation Clinical Trial
— OMECARDOfficial title:
" Etude du Transcriptome Complet Lors du Syndrome Post-arrêt Cardiaque " Transcriptome Assessment After Cardiac Arrest
Verified date | September 2022 |
Source | Assistance Publique - Hôpitaux de Paris |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to determine whether the blood transcriptome of patients resuscitated after out-of-hospital could be an early predictor of the neurological outcome.
Status | Completed |
Enrollment | 60 |
Est. completion date | February 10, 2022 |
Est. primary completion date | February 10, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Age between 18 and 80 years - Delay between patients collapse and resumption of spontaneous circulation (ROSC) < 60 minutes - Comatose patients ROSC with Glasgow score < 7 - Patient already registered in the social security system - Consent of a family member, if able to understand in the emergency context, or attestation of emergency situation with a follow-up information notice Exclusion Criteria: - Cardiac arrest supposed to be provoked by trauma or sepsis |
Country | Name | City | State |
---|---|---|---|
France | Hôpital Cochin, Assistance Publique Hôpitaux de Paris | Paris |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris | Ecole Nationale Vétérinaire d'Alfort, Institut National de la Santé Et de la Recherche Médicale, France, National Research Agency, France, Université Paris Est Créteil, University of Paris 5 - Rene Descartes |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Early Transcriptome at hospital admission | Blood samples will be collected for each patient early after admission at hospital and blood whole transcriptome will be assessed by RNA sequencing | Day 0 | |
Primary | Pittsburgh Cerebral Performance Category at Day 60 | Pittsburgh Cerebral Performance Category will be evaluated for each patient at day 60 | Day 60 | |
Secondary | Transcriptome at day 1 | Blood samples will be collected for each patient at day 1 and blood whole transcriptome will be assessed by RNA sequencing | Day 1 | |
Secondary | Transcriptome at day 3 | Blood samples will be collected for each patient at day 3 and blood whole transcriptome will be assessed by RNA sequencing | Day 3 | |
Secondary | Pittsburgh Cerebral Performance Category at Day 28 | Pittsburgh Cerebral Performance Category will be evaluated for each patient at day 28 | day 28 | |
Secondary | Number of participants with death at day 28 | day 28 | ||
Secondary | Number of participants with death at day 60 | day 60 |