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Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis

Endothelial Dysfunction Clinical Trial

Official title:
Predictive Value of Glycocalyx Biomarkers in Mechanical Ventilation of Patients With ARDS for Clinical Prognosis and Long-term Pulmonary Fibrosis

Clinical Trial Summary

ARDS is a severe disease in ICU, and could induce high mortality. Glycocalyx is an important matrix construction which covers endothelial cells, it could protect endothelial cells injury and the glycocalyx biomarkers could predict pulmonary injury.

Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03854565
Study type Observational [Patient Registry]
Source Southeast University, China
Contact Chun C Pan, Dr
Phone +862583262550
Email panchun1982@gmail.com
Status Not yet recruiting
Phase
Start date May 1, 2019
Completion date December 31, 2019
View Details
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