Previously Treated Non-Small Cell Lung Cancer Clinical Trial
Official title:
LUNGMAP: A Master Protocol To Evaluate Biomarker-Driven Therapies And Immunotherapies In Previously-Treated Non-Small Cell Lung Cancer (Lung-Map Screening Study)
This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protocol (Lung-MAP). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will be assigned to compare new targeted cancer therapy, designed to block the growth and spread of cancer, or combinations to standard of care therapy with the ultimate goal of being able to approve new targeted therapies in this setting. In addition, the protocol includes non-match sub-studies which will include all screened patients not eligible for any of the biomarker-driven sub-studies.
| Status | Recruiting |
| Enrollment | 10000 |
| Est. completion date | January 28, 2029 |
| Est. primary completion date | January 28, 2029 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | 5.1 Registration Step 0: 1. Patients who need the fresh biopsy must also submit whole blood for ctDNA testing (see Section 15.3). These patients must be registered to Step 0 to obtain a patient ID number for the submission. Patients registered to Step 0 are not registered to the LUNGMAP protocol. To participate in LUNGMAP, patients must be registered to Step 1 after evaluation of patient eligibility, including tumor tissue adequacy, per protocol Section 5.1, Step 1. Patients registered at Step 0 must use the same SWOG patient ID for registration at Step 1. Step 1: 2. Patients must have pathologically proven non-small cell lung cancer (all histologic types) confirmed by tumor biopsy and/or fine-needle aspiration. Disease must be Stage IV as defined in Section 4.0, or recurrent. The primary diagnosis of non-small cell lung cancer should be established using the current WHO/IASLC-classification of Thoracic Malignancies. All histologies, including mixed, are allowed. 3. Patients must either be eligible to be screened at progression on prior treatment or to be pre-screened prior to progression on current treatment. These criteria are: 1. Screening at progression on prior treatment: To be eligible for screening at progression, patients must have received at least one line of systemic therapy for any stage of disease (Stages I-IV) and must have progressed during or following their most recent line of therapy. - For patients whose prior systemic therapy was for Stage I-III disease only (i.e. patient has not received any treatment for Stage IV or recurrent disease), disease progression on platinum-based chemotherapy must have occurred within one year from the last date that patient received that therapy. For patients treated with consolidation anti-PD-1 or anti-PD-L1 therapy for Stage III disease, disease progression on consolidation anti-PD-1 or anti-PD-L1 therapy must have occurred within one year from the date or initiation of such therapy. - For patients whose prior therapy was for Stage IV or recurrent disease, the patient must have received at least one line of a platinum-based chemotherapy regimen or anti-PD-1/PD-L1 therapy, alone or in combination (e.g. Nivolumab or Pembrolizumab). 2. Pre-Screening prior to progression on current treatment: To be eligible for pre-screening, current treatment must be for Stage IV or recurrent disease and patient must have received at least one dose of the current regimen. Patients must have previously received or currently be receiving a platinum-based chemotherapy regimen or anti-PD-1/PD-L1 therapy, alone or in combination (e.g. Nivolumab or Pembrolizumab). Patients on first-line treatment are eligible upon receiving Cycle 1, Day 1 infusion. Note: Patients will not receive their sub-study assignment until they progress and the LUNGMAP Notice of Progression is submitted. 4. Patients must have adequate tumor tissue available, defined as = 20% tumor cells and = 0.2 mm3 tumor volume. - The local interpreting pathologist must review the specimen. - The pathologist must sign the LUNGMAP Local Pathology Review Form confirming tissue adequacy prior to Step 1 registration. Patients must agree to have this tissue submitted to Foundation Medicine for common broad platform CLIA biomarker profiling, PD-L1, and c-MET IHC (see Section 15.2). If archival tumor material is exhausted, then a new fresh tumor biopsy that is formalin-fixed and paraffin-embedded (FFPE) must be obtained. Patients who need the fresh biopsy must also submit whole peripheral blood for ctDNA testing. A tumor block or FFPE slides 4-5 microns thick must be submitted. Bone biopsies are not allowed. If FFPE slides are to be submitted, at least 12 unstained slides plus an H&E stained slide, or 13 unstained slides must be submitted. However, it is strongly recommended that 20 FFPE slides be submitted. Note: Previous next-generation DNA sequencing (NGS) will be repeated if done outside this study for sub-study assignment. Patients must agree to have any tissue that remains after testing retained for the use of sub-study Translational Medicine (TM) studies at the time of consent the patient is enrolled in. 5. Patients with known EGFR sensitizing mutations, EGFR T790M mutation, ALK gene fusion, ROS 1 gene rearrangement, or BRAF V600E mutation are not eligible unless they have progressed following all standard of care targeted therapy. EGFR/ALK/ROS/BRAF testing is not required prior to Step 1 registration, as it is included in the Foundation One testing for screening/pre-screening. 6. Patients must have Zubrod performance status 0-1 (see Section 10.2) documented within 28 days prior to Step 1 registration. 7. Patients must be = 18 years of age. 8. Patients must also be offered participation in banking for future use of specimens as described in Section 15.0. 9. Patients must be willing to provide prior smoking history as required on the LUNGMAP Onstudy Form. 10. As a part of the OPEN registration process (see Section 13.4 for OPEN access instructions) the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system. 11. Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines. 12. U.S. patients who can complete the survey and the interview by telephone or email in English must be offered participation in the S1400GEN Survey Ancillary Study if local institution's policies allow participants to receive the Amazon gift card (see Sections 15.7 and 18.5). Patients at institutions that cannot offer the survey must still participate in the main study. |
| Country | Name | City | State |
|---|---|---|---|
| United States | Hawaii Cancer Care - Savio | 'Aiea | Hawaii |
| United States | Pali Momi Medical Center | 'Aiea | Hawaii |
| United States | Queen's Cancer Center - Pearlridge | 'Aiea | Hawaii |
| United States | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii |
| United States | Lovelace Medical Center-Saint Joseph Square | Albuquerque | New Mexico |
| United States | New Mexico Oncology Hematology Consultants | Albuquerque | New Mexico |
| United States | Presbyterian Kaseman Hospital | Albuquerque | New Mexico |
| United States | University of New Mexico Cancer Center | Albuquerque | New Mexico |
| United States | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania |
| United States | Aultman Alliance Community Hospital | Alliance | Ohio |
| United States | The Don and Sybil Harrington Cancer Center | Amarillo | Texas |
| United States | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah |
| United States | Mary Greeley Medical Center | Ames | Iowa |
| United States | McFarland Clinic PC - Ames | Ames | Iowa |
| United States | Community Hospital of Anaconda | Anaconda | Montana |
| United States | Kaiser Permanente-Anaheim | Anaheim | California |
| United States | Alaska Oncology and Hematology LLC | Anchorage | Alaska |
| United States | Anchorage Oncology Centre | Anchorage | Alaska |
| United States | Katmai Oncology Group | Anchorage | Alaska |
| United States | Providence Alaska Medical Center | Anchorage | Alaska |
| United States | AnMed Health Cancer Center | Anderson | South Carolina |
| United States | Saint Joseph Mercy Hospital | Ann Arbor | Michigan |
| United States | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan |
| United States | Anne Arundel Medical Center | Annapolis | Maryland |
| United States | Langlade Hospital and Cancer Center | Antigo | Wisconsin |
| United States | Kaiser Permanente-Deer Valley Medical Center | Antioch | California |
| United States | Ascension Saint Elizabeth Hospital | Appleton | Wisconsin |
| United States | PCR Oncology | Arroyo Grande | California |
| United States | Randolph Hospital | Asheboro | North Carolina |
| United States | Mission Hospital | Asheville | North Carolina |
| United States | Duluth Clinic Ashland | Ashland | Wisconsin |
| United States | King's Daughter's Medical Center | Ashland | Kentucky |
| United States | Northwest Wisconsin Cancer Center | Ashland | Wisconsin |
| United States | Emory Saint Joseph's Hospital | Atlanta | Georgia |
| United States | Emory University Hospital Midtown | Atlanta | Georgia |
| United States | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia |
| United States | Grady Health System | Atlanta | Georgia |
| United States | Northside Hospital | Atlanta | Georgia |
| United States | MultiCare Auburn Medical Center | Auburn | Washington |
| United States | Sutter Auburn Faith Hospital | Auburn | California |
| United States | Augusta University Medical Center | Augusta | Georgia |
| United States | Harold Alfond Center for Cancer Care | Augusta | Maine |
| United States | Rocky Mountain Regional VA Medical Center | Aurora | Colorado |
| United States | University of Colorado Hospital | Aurora | Colorado |
| United States | Mount Sinai Comprehensive Cancer Center at Aventura | Aventura | Florida |
| United States | Kaiser Permanente-Baldwin Park | Baldwin Park | California |
| United States | Greater Baltimore Medical Center | Baltimore | Maryland |
| United States | Saint Agnes Hospital | Baltimore | Maryland |
| United States | Sinai Hospital of Baltimore | Baltimore | Maryland |
| United States | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland |
| United States | Eastern Maine Medical Center | Bangor | Maine |
| United States | Flaget Memorial Hospital | Bardstown | Kentucky |
| United States | Louisiana Hematology Oncology Associates LLC | Baton Rouge | Louisiana |
| United States | LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana |
| United States | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana |
| United States | Medical Center of Baton Rouge | Baton Rouge | Louisiana |
| United States | Ochsner High Grove | Baton Rouge | Louisiana |
| United States | Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge | Louisiana |
| United States | Bronson Battle Creek | Battle Creek | Michigan |
| United States | UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio |
| United States | UM Upper Chesapeake Medical Center | Bel Air | Maryland |
| United States | Overlake Medical Center | Bellevue | Washington |
| United States | Kaiser Permanente-Bellflower | Bellflower | California |
| United States | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington |
| United States | Strecker Cancer Center-Belpre | Belpre | Ohio |
| United States | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota |
| United States | Saint Charles Health System | Bend | Oregon |
| United States | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California |
| United States | Central Vermont Medical Center/National Life Cancer Treatment | Berlin | Vermont |
| United States | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania |
| United States | University of Iowa Healthcare Cancer Services Quad Cities | Bettendorf | Iowa |
| United States | Beverly Hospital | Beverly | Massachusetts |
| United States | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine |
| United States | Billings Clinic Cancer Center | Billings | Montana |
| United States | Veterans Administration Medical Center - Birmingham | Birmingham | Alabama |
| United States | Sanford Bismarck Medical Center | Bismarck | North Dakota |
| United States | Illinois CancerCare-Bloomington | Bloomington | Illinois |
| United States | Prisma Health Cancer Institute - Spartanburg | Boiling Springs | South Carolina |
| United States | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho |
| United States | Saint Luke's Cancer Institute - Boise | Boise | Idaho |
| United States | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri |
| United States | McFarland Clinic PC-Boone | Boone | Iowa |
| United States | Bozeman Deaconess Hospital | Bozeman | Montana |
| United States | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota |
| United States | Northeast Georgia Medical Center Braselton | Braselton | Georgia |
| United States | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington |
| United States | Lafayette Family Cancer Center-EMMC | Brewer | Maine |
| United States | IHA Hematology Oncology Consultants-Brighton | Brighton | Michigan |
| United States | Saint Joseph Mercy Brighton | Brighton | Michigan |
| United States | James J Peters VA Medical Center | Bronx | New York |
| United States | Montefiore Medical Center-Einstein Campus | Bronx | New York |
| United States | Ascension Southeast Wisconsin Hospital - Elmbrook Campus | Brookfield | Wisconsin |
| United States | Henry Ford Cancer Institute-Downriver | Brownstown | Michigan |
| United States | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania |
| United States | Roswell Park Cancer Institute | Buffalo | New York |
| United States | Kaiser Permanente-Burke Medical Center | Burke | Virginia |
| United States | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin |
| United States | Cone Health Cancer Center at Alamance Regional | Burlington | North Carolina |
| United States | Lahey Hospital and Medical Center | Burlington | Massachusetts |
| United States | University of Vermont and State Agricultural College | Burlington | Vermont |
| United States | University of Vermont Medical Center | Burlington | Vermont |
| United States | Fairview Ridges Hospital | Burnsville | Minnesota |
| United States | Minnesota Oncology - Burnsville | Burnsville | Minnesota |
| United States | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana |
| United States | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho |
| United States | Aultman Health Foundation | Canton | Ohio |
| United States | IHA Hematology Oncology Consultants-Canton | Canton | Michigan |
| United States | Illinois CancerCare-Canton | Canton | Illinois |
| United States | Mercy Hematology and Oncology Associates Inc | Canton | Ohio |
| United States | Mercy Medical Center | Canton | Ohio |
| United States | Saint Joseph Mercy Canton | Canton | Michigan |
| United States | Saint Francis Medical Center | Cape Girardeau | Missouri |
| United States | Southeast Cancer Center | Cape Girardeau | Missouri |
| United States | Mercy San Juan Medical Center | Carmichael | California |
| United States | Illinois CancerCare-Carthage | Carthage | Illinois |
| United States | Rex Hematology Oncology Associates-Cary | Cary | North Carolina |
| United States | Sandra L Maxwell Cancer Center | Cedar City | Utah |
| United States | Mercy Hospital | Cedar Rapids | Iowa |
| United States | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa |
| United States | Centralia Oncology Clinic | Centralia | Illinois |
| United States | Chambersburg Hospital | Chambersburg | Pennsylvania |
| United States | Cancer Center of Kansas - Chanute | Chanute | Kansas |
| United States | Geauga Hospital | Chardon | Ohio |
| United States | Medical University of South Carolina | Charleston | South Carolina |
| United States | Ralph H Johnson VA Medical Center | Charleston | South Carolina |
| United States | West Virginia University Charleston Division | Charleston | West Virginia |
| United States | Novant Health Presbyterian Medical Center | Charlotte | North Carolina |
| United States | University of Virginia Cancer Center | Charlottesville | Virginia |
| United States | IHA Hematology Oncology Consultants-Chelsea | Chelsea | Michigan |
| United States | Saint Joseph Mercy Chelsea | Chelsea | Michigan |
| United States | Saint Luke's Hospital | Chesterfield | Missouri |
| United States | John H Stroger Jr Hospital of Cook County | Chicago | Illinois |
| United States | Northwestern University | Chicago | Illinois |
| United States | University of Chicago Comprehensive Cancer Center | Chicago | Illinois |
| United States | Adena Regional Medical Center | Chillicothe | Ohio |
| United States | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin |
| United States | Bethesda North Hospital | Cincinnati | Ohio |
| United States | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio |
| United States | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon |
| United States | Case Western Reserve University | Cleveland | Ohio |
| United States | Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio |
| United States | Cleveland Clinic Foundation | Cleveland | Ohio |
| United States | Louis Stokes Cleveland VA Medical Center | Cleveland | Ohio |
| United States | Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina |
| United States | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan |
| United States | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa |
| United States | Mercy Cancer Center-West Lakes | Clive | Iowa |
| United States | Billings Clinic-Cody | Cody | Wyoming |
| United States | Kootenai Medical Center | Coeur d'Alene | Idaho |
| United States | Main Line Health Center-Collegeville | Collegeville | Pennsylvania |
| United States | Baptist Memorial Hospital and Cancer Center-Collierville | Collierville | Tennessee |
| United States | Memorial Hospital North | Colorado Springs | Colorado |
| United States | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado |
| United States | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado |
| United States | UCHealth Memorial Hospital Central | Colorado Springs | Colorado |
| United States | Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi |
| United States | Columbus Oncology and Hematology Associates Inc | Columbus | Ohio |
| United States | Doctors Hospital | Columbus | Ohio |
| United States | Grant Medical Center | Columbus | Ohio |
| United States | Mount Carmel East Hospital | Columbus | Ohio |
| United States | Mount Carmel Health Center West | Columbus | Ohio |
| United States | Ohio State University Comprehensive Cancer Center | Columbus | Ohio |
| United States | Riverside Methodist Hospital | Columbus | Ohio |
| United States | The Mark H Zangmeister Center | Columbus | Ohio |
| United States | New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire |
| United States | Cookeville Regional Medical Center | Cookeville | Tennessee |
| United States | Mercy Hospital | Coon Rapids | Minnesota |
| United States | Mary Imogene Bassett Hospital | Cooperstown | New York |
| United States | UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida |
| United States | Commonwealth Cancer Center-Corbin | Corbin | Kentucky |
| United States | Northshore Oncology Associates-Covington | Covington | Louisiana |
| United States | Greater Regional Medical Center | Creston | Iowa |
| United States | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri |
| United States | Western Maryland Regional Medical Center | Cumberland | Maryland |
| United States | Parkland Memorial Hospital | Dallas | Texas |
| United States | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas |
| United States | Hematology Oncology Consultants Limited-Darien | Darien | Illinois |
| United States | Genesis Cancer Care Institute | Davenport | Iowa |
| United States | Genesis Medical Center - East Campus | Davenport | Iowa |
| United States | Iowa Cancer Specialists | Davenport | Iowa |
| United States | Henry Ford Medical Center-Fairlane | Dearborn | Michigan |
| United States | Atlanta VA Medical Center | Decatur | Georgia |
| United States | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois |
| United States | Decatur Memorial Hospital | Decatur | Illinois |
| United States | Essentia Health - Deer River Clinic | Deer River | Minnesota |
| United States | UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida |
| United States | Delaware Health Center-Grady Cancer Center | Delaware | Ohio |
| United States | Grady Memorial Hospital | Delaware | Ohio |
| United States | Porter Adventist Hospital | Denver | Colorado |
| United States | SCL Health Saint Joseph Hospital | Denver | Colorado |
| United States | Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut |
| United States | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa |
| United States | Mercy Medical Center - Des Moines | Des Moines | Iowa |
| United States | Ascension Saint John Hospital | Detroit | Michigan |
| United States | Henry Ford Hospital | Detroit | Michigan |
| United States | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan |
| United States | Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota |
| United States | Illinois CancerCare-Dixon | Dixon | Illinois |
| United States | Cancer Center of Kansas - Dodge City | Dodge City | Kansas |
| United States | Bayhealth Hospital Kent Campus | Dover | Delaware |
| United States | Advocate Good Samaritan Hospital | Downers Grove | Illinois |
| United States | City of Hope Comprehensive Cancer Center | Duarte | California |
| United States | Dublin Methodist Hospital | Dublin | Ohio |
| United States | Essentia Health Cancer Center | Duluth | Minnesota |
| United States | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota |
| United States | Miller-Dwan Hospital | Duluth | Minnesota |
| United States | Northside Hospital - Duluth | Duluth | Georgia |
| United States | Mercy Medical Center | Durango | Colorado |
| United States | Duke University Medical Center | Durham | North Carolina |
| United States | Durham VA Medical Center | Durham | North Carolina |
| United States | Prisma Health Cancer Institute - Easley | Easley | South Carolina |
| United States | Great Lakes Cancer Management Specialists-Doctors Park | East China Township | Michigan |
| United States | Fox Chase Cancer Center - East Norriton Hospital Outpatient Center | East Norriton | Pennsylvania |
| United States | University of Maryland Shore Medical Center at Easton | Easton | Maryland |
| United States | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin |
| United States | Fairview Southdale Hospital | Edina | Minnesota |
| United States | Swedish Cancer Institute-Edmonds | Edmonds | Washington |
| United States | Carle Physician Group-Effingham | Effingham | Illinois |
| United States | Crossroads Cancer Center | Effingham | Illinois |
| United States | Cancer Center of Kansas - El Dorado | El Dorado | Kansas |
| United States | Baptist Health Hardin | Elizabethtown | Kentucky |
| United States | Mercy Cancer Center - Elk Grove | Elk Grove | California |
| United States | Arnot Ogden Medical Center/Falck Cancer Center | Elmira | New York |
| United States | Walter Knox Memorial Hospital | Emmett | Idaho |
| United States | Ephrata Cancer Center | Ephrata | Pennsylvania |
| United States | Ephrata Community Hospital | Ephrata | Pennsylvania |
| United States | Green Bay Oncology - Escanaba | Escanaba | Michigan |
| United States | Illinois CancerCare-Eureka | Eureka | Illinois |
| United States | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois |
| United States | Main Line Health Center-Exton | Exton | Pennsylvania |
| United States | Fairbanks Memorial Hospital | Fairbanks | Alaska |
| United States | Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut |
| United States | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota |
| United States | Sanford Broadway Medical Center | Fargo | North Dakota |
| United States | Sanford Roger Maris Cancer Center | Fargo | North Dakota |
| United States | Parkland Health Center - Farmington | Farmington | Missouri |
| United States | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota |
| United States | Armes Family Cancer Center | Findlay | Ohio |
| United States | Genesee Cancer and Blood Disease Treatment Center | Flint | Michigan |
| United States | Genesee Hematology Oncology PC | Flint | Michigan |
| United States | Genesys Hurley Cancer Institute | Flint | Michigan |
| United States | Hurley Medical Center | Flint | Michigan |
| United States | Aurora Health Center-Fond du Lac | Fond Du Lac | Wisconsin |
| United States | Saint Agnes Hospital/Agnesian Cancer Center | Fond Du Lac | Wisconsin |
| United States | Kaiser Permanente-Fontana | Fontana | California |
| United States | Cancer Care and Hematology-Fort Collins | Fort Collins | Colorado |
| United States | Poudre Valley Hospital | Fort Collins | Colorado |
| United States | McFarland Clinic PC-Trinity Cancer Center | Fort Dodge | Iowa |
| United States | Parkview Regional Medical Center | Fort Wayne | Indiana |
| United States | UT Southwestern/Simmons Cancer Center-Fort Worth | Fort Worth | Texas |
| United States | Essentia Health - Fosston | Fosston | Minnesota |
| United States | Beebe South Coastal Health Campus | Frankford | Delaware |
| United States | Ascension Saint Francis - Reiman Cancer Center | Franklin | Wisconsin |
| United States | Dayton Physicians LLC-Atrium | Franklin | Ohio |
| United States | Kaiser Permanente-Fremont | Fremont | California |
| United States | Palo Alto Medical Foundation-Fremont | Fremont | California |
| United States | Washington Hospital | Fremont | California |
| United States | Fresno Cancer Center | Fresno | California |
| United States | Kaiser Permanente-Fresno | Fresno | California |
| United States | Unity Hospital | Fridley | Minnesota |
| United States | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho |
| United States | Saint Jude Medical Center | Fullerton | California |
| United States | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina |
| United States | Northeast Georgia Medical Center-Gainesville | Gainesville | Georgia |
| United States | Kaiser Permanente-Gaithersburg Medical Center | Gaithersburg | Maryland |
| United States | Illinois CancerCare-Galesburg | Galesburg | Illinois |
| United States | Rex Hematology Oncology Associates-Garner | Garner | North Carolina |
| United States | Aurora Health Care Germantown Health Center | Germantown | Wisconsin |
| United States | Adams Cancer Center | Gettysburg | Pennsylvania |
| United States | MultiCare Gig Harbor Medical Park | Gig Harbor | Washington |
| United States | Glens Falls Hospital | Glens Falls | New York |
| United States | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois |
| United States | Addison Gilbert Hospital | Gloucester | Massachusetts |
| United States | Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina |
| United States | Wayne Memorial Hospital | Goldsboro | North Carolina |
| United States | CTCA at Western Regional Medical Center | Goodyear | Arizona |
| United States | Goshen Center for Cancer Care | Goshen | Indiana |
| United States | Aurora Cancer Care-Grafton | Grafton | Wisconsin |
| United States | CHI Health Saint Francis | Grand Island | Nebraska |
| United States | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan |
| United States | Mercy Health Saint Mary's | Grand Rapids | Michigan |
| United States | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan |
| United States | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana |
| United States | Great Falls Clinic | Great Falls | Montana |
| United States | UCHealth Greeley Hospital | Greeley | Colorado |
| United States | Aurora BayCare Medical Center | Green Bay | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin |
| United States | Cone Health Cancer Center | Greensboro | North Carolina |
| United States | Prisma Health Cancer Institute - Butternut | Greenville | South Carolina |
| United States | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina |
| United States | Prisma Health Cancer Institute - Faris | Greenville | South Carolina |
| United States | Prisma Health Greenville Memorial Hospital | Greenville | South Carolina |
| United States | Gibbs Cancer Center-Pelham | Greer | South Carolina |
| United States | Prisma Health Cancer Institute - Greer | Greer | South Carolina |
| United States | Baptist Cancer Center-Grenada | Grenada | Mississippi |
| United States | Academic Hematology Oncology Specialists | Grosse Pointe Woods | Michigan |
| United States | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods | Michigan |
| United States | Smilow Cancer Hospital Care Center - Guiford | Guilford | Connecticut |
| United States | Gulfport Memorial Hospital | Gulfport | Mississippi |
| United States | Cherry Tree Cancer Center | Hanover | Pennsylvania |
| United States | Kaiser Permanente - Harbor City | Harbor City | California |
| United States | UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania |
| United States | UPMC Pinnacle Harrisburg | Harrisburg | Pennsylvania |
| United States | Hartford Hospital | Hartford | Connecticut |
| United States | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut |
| United States | HaysMed University of Kansas Health System | Hays | Kansas |
| United States | Saint Peter's Community Hospital | Helena | Montana |
| United States | 21st Century Oncology-Henderson | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada |
| United States | Las Vegas Cancer Center-Henderson | Henderson | Nevada |
| United States | Las Vegas Urology - Green Valley | Henderson | Nevada |
| United States | Las Vegas Urology - Pebble | Henderson | Nevada |
| United States | OptumCare Cancer Care at Seven Hills | Henderson | Nevada |
| United States | Urology Specialists of Nevada - Green Valley | Henderson | Nevada |
| United States | Margaret R Pardee Memorial Hospital | Hendersonville | North Carolina |
| United States | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania |
| United States | Essentia Health Hibbing Clinic | Hibbing | Minnesota |
| United States | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois |
| United States | UCHealth Highlands Ranch Hospital | Highlands Ranch | Colorado |
| United States | Edward Hines Jr VA Hospital | Hines | Illinois |
| United States | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida |
| United States | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii |
| United States | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii |
| United States | Island Urology | Honolulu | Hawaii |
| United States | Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii |
| United States | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii |
| United States | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii |
| United States | Queen's Cancer Center - Kuakini | Honolulu | Hawaii |
| United States | Queen's Medical Center | Honolulu | Hawaii |
| United States | Straub Clinic and Hospital | Honolulu | Hawaii |
| United States | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii |
| United States | University of Hawaii Cancer Center | Honolulu | Hawaii |
| United States | Oncology Center of The South Incorporated | Houma | Louisiana |
| United States | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas |
| United States | M D Anderson Cancer Center | Houston | Texas |
| United States | Edwards Comprehensive Cancer Center | Huntington | West Virginia |
| United States | Saint Mary's Medical Center | Huntington | West Virginia |
| United States | Cancer Center of Kansas-Independence | Independence | Kansas |
| United States | Franciscan Health Indianapolis | Indianapolis | Indiana |
| United States | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana |
| United States | Iowa City VA Healthcare System | Iowa City | Iowa |
| United States | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa |
| United States | Kaiser Permanente-Irvine | Irvine | California |
| United States | Swedish Cancer Institute-Issaquah | Issaquah | Washington |
| United States | Allegiance Health | Jackson | Michigan |
| United States | University of Mississippi Medical Center | Jackson | Mississippi |
| United States | Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina |
| United States | Essentia Health - Jamestown Clinic | Jamestown | North Dakota |
| United States | Mercyhealth Hospital and Cancer Center - Janesville | Janesville | Wisconsin |
| United States | McFarland Clinic PC-Jefferson | Jefferson | Iowa |
| United States | Emory Johns Creek Hospital | Johns Creek | Georgia |
| United States | Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas |
| United States | Mercy Hospital Joplin | Joplin | Missouri |
| United States | Borgess Medical Center | Kalamazoo | Michigan |
| United States | Bronson Methodist Hospital | Kalamazoo | Michigan |
| United States | West Michigan Cancer Center | Kalamazoo | Michigan |
| United States | Kalispell Regional Medical Center | Kalispell | Montana |
| United States | Saint Luke's Hospital of Kansas City | Kansas City | Missouri |
| United States | Truman Medical Centers | Kansas City | Missouri |
| United States | University of Kansas Cancer Center | Kansas City | Kansas |
| United States | University of Kansas Cancer Center - North | Kansas City | Missouri |
| United States | University of Kansas Cancer Center-West | Kansas City | Kansas |
| United States | CHI Health Good Samaritan | Kearney | Nebraska |
| United States | Ochsner Medical Center Kenner | Kenner | Louisiana |
| United States | Kadlec Clinic Hematology and Oncology | Kennewick | Washington |
| United States | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin |
| United States | Novant Health Cancer Institute - Kernersville | Kernersville | North Carolina |
| United States | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois |
| United States | Cancer Center of Kansas-Kingman | Kingman | Kansas |
| United States | Seattle Cancer Care Alliance at EvergreenHealth | Kirkland | Washington |
| United States | Gundersen Lutheran Medical Center | La Crosse | Wisconsin |
| United States | UC San Diego Moores Cancer Center | La Jolla | California |
| United States | Marshfield Clinic - Ladysmith Center | Ladysmith | Wisconsin |
| United States | City of Hope Antelope Valley | Lancaster | California |
| United States | Fairfield Medical Center | Lancaster | Ohio |
| United States | Sparrow Hospital | Lansing | Michigan |
| United States | Memorial Medical Center - Las Cruces | Las Cruces | New Mexico |
| United States | 21st Century Oncology | Las Vegas | Nevada |
| United States | 21st Century Oncology-Fort Apache | Las Vegas | Nevada |
| United States | 21st Century Oncology-Vegas Tenaya | Las Vegas | Nevada |
| United States | Ann M Wierman MD LTD | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada |
| United States | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada |
| United States | HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada |
| United States | Hope Cancer Care of Nevada | Las Vegas | Nevada |
| United States | Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada |
| United States | Las Vegas Urology - Cathedral Rock | Las Vegas | Nevada |
| United States | Las Vegas Urology - Pecos | Las Vegas | Nevada |
| United States | Las Vegas Urology - Smoke Ranch | Las Vegas | Nevada |
| United States | Las Vegas Urology - Sunset | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at Charleston | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada |
| United States | OptumCare Cancer Care at MountainView | Las Vegas | Nevada |
| United States | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada |
| United States | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Central | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Northwest | Las Vegas | Nevada |
| United States | Urology Specialists of Nevada - Southwest | Las Vegas | Nevada |
| United States | Lawrence Memorial Hospital | Lawrence | Kansas |
| United States | Northside Hospital - Gwinnett | Lawrenceville | Georgia |
| United States | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma |
| United States | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire |
| United States | Sechler Family Cancer Center | Lebanon | Pennsylvania |
| United States | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri |
| United States | University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri |
| United States | Beebe Medical Center | Lewes | Delaware |
| United States | Saint Joseph Hospital East | Lexington | Kentucky |
| United States | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky |
| United States | University of Kentucky/Markey Cancer Center | Lexington | Kentucky |
| United States | Cancer Center of Kansas-Liberal | Liberal | Kansas |
| United States | Nebraska Hematology and Oncology | Lincoln | Nebraska |
| United States | Southeast Nebraska Cancer Center - 68th Street Place | Lincoln | Nebraska |
| United States | University of Arkansas for Medical Sciences | Little Rock | Arkansas |
| United States | Littleton Adventist Hospital | Littleton | Colorado |
| United States | Hope Cancer Clinic | Livonia | Michigan |
| United States | Saint Mary Mercy Hospital | Livonia | Michigan |
| United States | Logan Regional Hospital | Logan | Utah |
| United States | Loma Linda University Medical Center | Loma Linda | California |
| United States | Veterans Affairs Loma Linda Healthcare System | Loma Linda | California |
| United States | Saint Joseph London | London | Kentucky |
| United States | UCHealth Lone Tree Health Center | Lone Tree | Colorado |
| United States | Tibor Rubin VA Medical Center | Long Beach | California |
| United States | Monmouth Medical Center | Long Branch | New Jersey |
| United States | Longmont United Hospital | Longmont | Colorado |
| United States | PeaceHealth Saint John Medical Center | Longview | Washington |
| United States | Cedars Sinai Medical Center | Los Angeles | California |
| United States | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California |
| United States | Kaiser Permanente-Cadillac | Los Angeles | California |
| United States | Baptist Health Louisville | Louisville | Kentucky |
| United States | Jewish Hospital | Louisville | Kentucky |
| United States | Jewish Hospital Medical Center Northeast | Louisville | Kentucky |
| United States | Saints Mary and Elizabeth Hospital | Louisville | Kentucky |
| United States | Medical Center of the Rockies | Loveland | Colorado |
| United States | Lowell General Hospital | Lowell | Massachusetts |
| United States | Covenant Medical Center-Lakeside | Lubbock | Texas |
| United States | Centra Lynchburg Hematology-Oncology Clinic Inc | Lynchburg | Virginia |
| United States | Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb | Michigan |
| United States | Illinois CancerCare-Macomb | Macomb | Illinois |
| United States | University of Wisconsin Hospital and Clinics | Madison | Wisconsin |
| United States | Norris Cotton Cancer Center-Manchester | Manchester | New Hampshire |
| United States | Solinsky Center for Cancer Care | Manchester | New Hampshire |
| United States | Cancer Center of Kansas-Manhattan | Manhattan | Kansas |
| United States | Holy Family Memorial Hospital | Manitowoc | Wisconsin |
| United States | Cleveland Clinic Cancer Center Mansfield | Mansfield | Ohio |
| United States | OhioHealth Mansfield Hospital | Mansfield | Ohio |
| United States | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota |
| United States | Saint John's Hospital - Healtheast | Maplewood | Minnesota |
| United States | Marietta Memorial Hospital | Marietta | Ohio |
| United States | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Marinette | Marinette | Wisconsin |
| United States | OhioHealth Marion General Hospital | Marion | Ohio |
| United States | McFarland Clinic PC-Marshalltown | Marshalltown | Iowa |
| United States | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin |
| United States | Fremont - Rideout Cancer Center | Marysville | California |
| United States | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois |
| United States | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio |
| United States | Loyola University Medical Center | Maywood | Illinois |
| United States | Kaiser Permanente Tysons Corner Medical Center | McLean | Virginia |
| United States | Cancer Center of Kansas - McPherson | McPherson | Kansas |
| United States | Cone Heath Cancer Center at Mebane | Mebane | North Carolina |
| United States | Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia |
| United States | Aspirus Medford Hospital | Medford | Wisconsin |
| United States | Riddle Memorial Hospital | Media | Pennsylvania |
| United States | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee |
| United States | Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin |
| United States | UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio |
| United States | Ascension Columbia Saint Mary's Hospital Ozaukee | Mequon | Wisconsin |
| United States | Midstate Medical Center | Meriden | Connecticut |
| United States | Idaho Urologic Institute-Meridian | Meridian | Idaho |
| United States | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho |
| United States | UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida |
| United States | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida |
| United States | Mount Sinai Medical Center | Miami Beach | Florida |
| United States | Woodland Cancer Care Center | Michigan City | Indiana |
| United States | UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio |
| United States | Bon Secours Saint Francis Medical Center | Midlothian | Virginia |
| United States | Bayhealth Hospital Sussex Campus | Milford | Delaware |
| United States | Ascension Columbia Saint Mary's Hospital - Milwaukee | Milwaukee | Wisconsin |
| United States | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin |
| United States | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin |
| United States | Aurora Sinai Medical Center | Milwaukee | Wisconsin |
| United States | Medical College of Wisconsin | Milwaukee | Wisconsin |
| United States | Abbott-Northwestern Hospital | Minneapolis | Minnesota |
| United States | Hennepin County Medical Center | Minneapolis | Minnesota |
| United States | Minneapolis VA Medical Center | Minneapolis | Minnesota |
| United States | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin |
| United States | Trinity Cancer Care Center | Minot | North Dakota |
| United States | Community Medical Hospital | Missoula | Montana |
| United States | University of South Alabama Mitchell Cancer Institute | Mobile | Alabama |
| United States | Kaiser Permanente-Modesto | Modesto | California |
| United States | Monticello Cancer Center | Monticello | Minnesota |
| United States | Virtua Samson Cancer Center | Moorestown | New Jersey |
| United States | Franciscan Health Mooresville | Mooresville | Indiana |
| United States | Saint Claire Regional Medical Center | Morehead | Kentucky |
| United States | Novant Health Cancer Institute - Mount Airy | Mount Airy | North Carolina |
| United States | Good Samaritan Regional Health Center | Mount Vernon | Illinois |
| United States | Knox Community Hospital | Mount Vernon | Ohio |
| United States | Palo Alto Medical Foundation-Camino Division | Mountain View | California |
| United States | Palo Alto Medical Foundation-Gynecologic Oncology | Mountain View | California |
| United States | ProHealth D N Greenwald Center | Mukwonago | Wisconsin |
| United States | Mercy Health Mercy Campus | Muskegon | Michigan |
| United States | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho |
| United States | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho |
| United States | Norris Cotton Cancer Center-Nashua | Nashua | New Hampshire |
| United States | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi |
| United States | The Hospital of Central Connecticut | New Britain | Connecticut |
| United States | Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut |
| United States | Yale University | New Haven | Connecticut |
| United States | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois |
| United States | Louisiana State University Health Science Center | New Orleans | Louisiana |
| United States | Ochsner Medical Center Jefferson | New Orleans | Louisiana |
| United States | University Medical Center New Orleans | New Orleans | Louisiana |
| United States | Cancer Center of Western Wisconsin | New Richmond | Wisconsin |
| United States | Mount Sinai Chelsea | New York | New York |
| United States | Mount Sinai Hospital | New York | New York |
| United States | Christiana Care Health System-Christiana Hospital | Newark | Delaware |
| United States | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware |
| United States | Helen F Graham Cancer Center | Newark | Delaware |
| United States | Licking Memorial Hospital | Newark | Ohio |
| United States | Medical Oncology Hematology Consultants PA | Newark | Delaware |
| United States | Providence Newberg Medical Center | Newberg | Oregon |
| United States | CTCA at Southeastern Regional Medical Center | Newnan | Georgia |
| United States | Cancer Center of Kansas - Newton | Newton | Kansas |
| United States | Lakeland Hospital Niles | Niles | Michigan |
| United States | Faith Regional Health Services Carson Cancer Center | Norfolk | Nebraska |
| United States | Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut |
| United States | University of Kansas Cancer Center at North Kansas City Hospital | North Kansas City | Missouri |
| United States | Great Plains Health Callahan Cancer Center | North Platte | Nebraska |
| United States | Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan |
| United States | Stephens Memorial Hospital | Norway | Maine |
| United States | Sutter Cancer Research Consortium | Novato | California |
| United States | Ascension Providence Hospitals - Novi | Novi | Michigan |
| United States | Henry Ford Medical Center-Columbus | Novi | Michigan |
| United States | Cancer Care Center of O'Fallon | O'Fallon | Illinois |
| United States | Kaiser Permanente Oakland-Broadway | Oakland | California |
| United States | Kaiser Permanente-Oakland | Oakland | California |
| United States | TidalHealth Richard A Henson Cancer Institute | Ocean Pines | Maryland |
| United States | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin |
| United States | Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin |
| United States | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma |
| United States | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma |
| United States | Olathe Health Cancer Center | Olathe | Kansas |
| United States | Nebraska Cancer Specialists - Omaha | Omaha | Nebraska |
| United States | Nebraska Methodist Hospital | Omaha | Nebraska |
| United States | Oncology Hematology West PC | Omaha | Nebraska |
| United States | Kaiser Permanente-Ontario | Ontario | California |
| United States | Saint Alphonsus Medical Center-Ontario | Ontario | Oregon |
| United States | Saint Joseph Hospital - Orange | Orange | California |
| United States | Smilow Cancer Hospital-Orange Care Center | Orange | Connecticut |
| United States | University of Chicago Medicine-Orland Park | Orland Park | Illinois |
| United States | Ascension Mercy Hospital | Oshkosh | Wisconsin |
| United States | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin |
| United States | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois |
| United States | Saint Luke's South Hospital | Overland Park | Kansas |
| United States | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas |
| United States | Owensboro Health Mitchell Memorial Cancer Center | Owensboro | Kentucky |
| United States | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi |
| United States | Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada |
| United States | Palo Alto Medical Foundation Health Care | Palo Alto | California |
| United States | Stanford Cancer Institute Palo Alto | Palo Alto | California |
| United States | Kaiser Permanente - Panorama City | Panorama City | California |
| United States | Paoli Memorial Hospital | Paoli | Pennsylvania |
| United States | Essentia Health - Park Rapids | Park Rapids | Minnesota |
| United States | Parker Adventist Hospital | Parker | Colorado |
| United States | University Hospitals Parma Medical Center | Parma | Ohio |
| United States | Cancer Center of Kansas - Parsons | Parsons | Kansas |
| United States | Singing River Hospital | Pascagoula | Mississippi |
| United States | Illinois CancerCare-Pekin | Pekin | Illinois |
| United States | Memorial Hospital West | Pembroke Pines | Florida |
| United States | Illinois CancerCare-Peoria | Peoria | Illinois |
| United States | Illinois CancerCare-Peru | Peru | Illinois |
| United States | Fox Chase Cancer Center | Philadelphia | Pennsylvania |
| United States | Temple University Hospital | Philadelphia | Pennsylvania |
| United States | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania |
| United States | FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina |
| United States | Ascension Via Christi - Pittsburg | Pittsburg | Kansas |
| United States | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania |
| United States | UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida |
| United States | Newland Medical Associates-Pontiac | Pontiac | Michigan |
| United States | Saint Joseph Mercy Oakland | Pontiac | Michigan |
| United States | Jefferson Healthcare | Port Townsend | Washington |
| United States | Kaiser Permanente Northwest | Portland | Oregon |
| United States | Oregon Health and Science University | Portland | Oregon |
| United States | Providence Portland Medical Center | Portland | Oregon |
| United States | Providence Saint Vincent Medical Center | Portland | Oregon |
| United States | Southern Ohio Medical Center | Portsmouth | Ohio |
| United States | Kootenai Cancer Center | Post Falls | Idaho |
| United States | Pottstown Hospital | Pottstown | Pennsylvania |
| United States | Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington |
| United States | Cancer Center of Kansas - Pratt | Pratt | Kansas |
| United States | Illinois CancerCare-Princeton | Princeton | Illinois |
| United States | Utah Valley Regional Medical Center | Provo | Utah |
| United States | MultiCare Good Samaritan Hospital | Puyallup | Washington |
| United States | Ascension All Saints Hospital | Racine | Wisconsin |
| United States | Aurora Cancer Care-Racine | Racine | Wisconsin |
| United States | Duke Raleigh Hospital | Raleigh | North Carolina |
| United States | Rex Cancer Center | Raleigh | North Carolina |
| United States | Rex Cancer Center of Wakefield | Raleigh | North Carolina |
| United States | Rex Hematology Oncology Associates-Blue Ridge | Raleigh | North Carolina |
| United States | Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California |
| United States | Eisenhower Medical Center | Rancho Mirage | California |
| United States | Northwest Hospital Center | Randallstown | Maryland |
| United States | Rapid City Regional Hospital | Rapid City | South Dakota |
| United States | University Hospitals Portage Medical Center | Ravenna | Ohio |
| United States | Penn State Health Saint Joseph Medical Center | Reading | Pennsylvania |
| United States | Kaiser Permanente-Redwood City | Redwood City | California |
| United States | Spectrum Health Reed City Hospital | Reed City | Michigan |
| United States | Beebe Health Campus | Rehoboth Beach | Delaware |
| United States | Annie Penn Memorial Hospital | Reidsville | North Carolina |
| United States | Radiation Oncology Associates | Reno | Nevada |
| United States | Renown Regional Medical Center | Reno | Nevada |
| United States | Saint Mary's Regional Medical Center | Reno | Nevada |
| United States | Valley Medical Center | Renton | Washington |
| United States | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin |
| United States | UT Southwestern Clinical Center at Richardson/Plano | Richardson | Texas |
| United States | Bon Secours Saint Mary's Hospital | Richmond | Virginia |
| United States | Kaiser Permanente-Richmond | Richmond | California |
| United States | VCU Massey Cancer Center at Stony Point | Richmond | Virginia |
| United States | Virginia Cancer Institute | Richmond | Virginia |
| United States | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia |
| United States | Presbyterian Rust Medical Center/Jorgensen Cancer Center | Rio Rancho | New Mexico |
| United States | Kaiser Permanente-Riverside | Riverside | California |
| United States | North Memorial Medical Health Center | Robbinsdale | Minnesota |
| United States | University of Rochester | Rochester | New York |
| United States | Great Lakes Cancer Management Specialists-Rochester Hills | Rochester Hills | Michigan |
| United States | OSF Saint Anthony Medical Center | Rockford | Illinois |
| United States | Mercy Cancer Center - Rocklin | Rocklin | California |
| United States | Penobscot Bay Medical Center | Rockport | Maine |
| United States | Rohnert Park Cancer Center | Rohnert Park | California |
| United States | Kaiser Permanente-Roseville | Roseville | California |
| United States | Sutter Roseville Medical Center | Roseville | California |
| United States | The Permanente Medical Group-Roseville Radiation Oncology | Roseville | California |
| United States | Kaiser Permanente - Sacramento | Sacramento | California |
| United States | Kaiser Permanente Downtown Commons | Sacramento | California |
| United States | Kaiser Permanente-South Sacramento | Sacramento | California |
| United States | Mercy Cancer Center - Sacramento | Sacramento | California |
| United States | South Sacramento Cancer Center | Sacramento | California |
| United States | Sutter Medical Center Sacramento | Sacramento | California |
| United States | University of California Davis Comprehensive Cancer Center | Sacramento | California |
| United States | Ascension Saint Mary's Hospital | Saginaw | Michigan |
| United States | Dixie Medical Center Regional Cancer Center | Saint George | Utah |
| United States | Saint Helena Hospital | Saint Helena | California |
| United States | Heartland Regional Medical Center | Saint Joseph | Missouri |
| United States | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan |
| United States | Marie Yeager Cancer Center | Saint Joseph | Michigan |
| United States | Mercy Hospital Saint Louis | Saint Louis | Missouri |
| United States | Mercy Hospital South | Saint Louis | Missouri |
| United States | Missouri Baptist Medical Center | Saint Louis | Missouri |
| United States | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri |
| United States | Siteman Cancer Center-South County | Saint Louis | Missouri |
| United States | Washington University School of Medicine | Saint Louis | Missouri |
| United States | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota |
| United States | Regions Hospital | Saint Paul | Minnesota |
| United States | United Hospital | Saint Paul | Minnesota |
| United States | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri |
| United States | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri |
| United States | Salem Hospital | Salem | Oregon |
| United States | Cancer Center of Kansas - Salina | Salina | Kansas |
| United States | Salina Regional Health Center | Salina | Kansas |
| United States | TidalHealth Peninsula Regional | Salisbury | Maryland |
| United States | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah |
| United States | Kaiser Permanente-San Diego Mission | San Diego | California |
| United States | Kaiser Permanente-San Diego Zion | San Diego | California |
| United States | California Pacific Medical Center-Pacific Campus | San Francisco | California |
| United States | Kaiser Permanente-San Francisco | San Francisco | California |
| United States | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California |
| United States | Kaiser Permanente San Leandro | San Leandro | California |
| United States | Kaiser Permanente-San Marcos | San Marcos | California |
| United States | Kaiser Permanente-San Rafael | San Rafael | California |
| United States | Kaiser San Rafael-Gallinas | San Rafael | California |
| United States | Kootenai Cancer Clinic | Sandpoint | Idaho |
| United States | Essentia Health Sandstone | Sandstone | Minnesota |
| United States | North Coast Cancer Care | Sandusky | Ohio |
| United States | UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio |
| United States | MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford | Maine |
| United States | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California |
| United States | Palo Alto Medical Foundation-Santa Cruz | Santa Cruz | California |
| United States | Kaiser Permanente-Santa Rosa | Santa Rosa | California |
| United States | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia |
| United States | Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania |
| United States | Regional West Medical Center Cancer Center | Scottsbluff | Nebraska |
| United States | TidalHealth Nanticoke / Allen Cancer Center | Seaford | Delaware |
| United States | Fred Hutchinson Cancer Research Center | Seattle | Washington |
| United States | Seattle Cancer Care Alliance | Seattle | Washington |
| United States | Seattle Cancer Care Alliance at Northwest Hospital | Seattle | Washington |
| United States | Swedish Medical Center-First Hill | Seattle | Washington |
| United States | University of Washington Medical Center - Montlake | Seattle | Washington |
| United States | PeaceHealth United General Medical Center | Sedro-Woolley | Washington |
| United States | Prisma Health Cancer Institute - Seneca | Seneca | South Carolina |
| United States | Saint Francis Regional Medical Center | Shakopee | Minnesota |
| United States | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin |
| United States | Henry Ford Macomb Health Center - Shelby Township | Shelby | Michigan |
| United States | Jewish Hospital Medical Center South | Shepherdsville | Kentucky |
| United States | Welch Cancer Center | Sheridan | Wyoming |
| United States | Genesis Cancer Center - Silvis | Silvis | Illinois |
| United States | Siouxland Regional Cancer Center | Sioux City | Iowa |
| United States | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota |
| United States | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota |
| United States | Suburban Hematology Oncology Associates - Snellville | Snellville | Georgia |
| United States | Robert Wood Johnson University Hospital Somerset | Somerville | New Jersey |
| United States | Memorial Hospital of South Bend | South Bend | Indiana |
| United States | VCU Community Memorial Health Center | South Hill | Virginia |
| United States | City of Hope South Pasadena | South Pasadena | California |
| United States | Maine Medical Partners - South Portland | South Portland | Maine |
| United States | Kaiser Permanente Cancer Treatment Center | South San Francisco | California |
| United States | Kaiser Permanente-South San Francisco | South San Francisco | California |
| United States | Ascension Providence Hospitals - Southfield | Southfield | Michigan |
| United States | Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi |
| United States | Spartanburg Medical Center | Spartanburg | South Carolina |
| United States | MultiCare Deaconess Cancer and Blood Specialty Center - Downtown | Spokane | Washington |
| United States | MultiCare Deaconess Cancer and Blood Specialty Center - North | Spokane | Washington |
| United States | MultiCare Deaconess Cancer and Blood Specialty Center - Valley | Spokane Valley | Washington |
| United States | Baystate Medical Center | Springfield | Massachusetts |
| United States | Memorial Medical Center | Springfield | Illinois |
| United States | Mercy Hospital Springfield | Springfield | Missouri |
| United States | Southern Illinois University School of Medicine | Springfield | Illinois |
| United States | Springfield Clinic | Springfield | Illinois |
| United States | Springfield Regional Cancer Center | Springfield | Ohio |
| United States | Springfield Regional Medical Center | Springfield | Ohio |
| United States | Stamford Hospital/Bennett Cancer Center | Stamford | Connecticut |
| United States | Novant Health Cancer Institute - Statesville | Statesville | North Carolina |
| United States | Marshfield Clinic Stevens Point Center | Stevens Point | Wisconsin |
| United States | Lakeview Hospital | Stillwater | Minnesota |
| United States | Kaiser Permanente-Stockton | Stockton | California |
| United States | Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio |
| United States | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin |
| United States | Missouri Baptist Sullivan Hospital | Sullivan | Missouri |
| United States | Aurora Medical Center in Summit | Summit | Wisconsin |
| United States | Palo Alto Medical Foundation-Sunnyvale | Sunnyvale | California |
| United States | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri |
| United States | ProMedica Flower Hospital | Sylvania | Ohio |
| United States | MultiCare Tacoma General Hospital | Tacoma | Washington |
| United States | Moffitt Cancer Center | Tampa | Florida |
| United States | Union Hospital | Terre Haute | Indiana |
| United States | Novant Health Cancer Institute - Thomasville | Thomasville | North Carolina |
| United States | University of Kansas Health System Saint Francis Campus | Topeka | Kansas |
| United States | Torrance Memorial Medical Center | Torrance | California |
| United States | Torrance Memorial Physician Network - Cancer Care | Torrance | California |
| United States | Smilow Cancer Hospital-Torrington Care Center | Torrington | Connecticut |
| United States | Munson Medical Center | Traverse City | Michigan |
| United States | Dayton Physicians LLC-Upper Valley | Troy | Ohio |
| United States | Upper Valley Medical Center | Troy | Ohio |
| United States | Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee | California |
| United States | Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut |
| United States | Cancer Treatment Centers of America | Tulsa | Oklahoma |
| United States | Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma |
| United States | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho |
| United States | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin |
| United States | MGC Hematology Oncology-Union | Union | South Carolina |
| United States | City of Hope Upland | Upland | California |
| United States | Carle Cancer Center | Urbana | Illinois |
| United States | Kaiser Permanente Medical Center-Vacaville | Vacaville | California |
| United States | Northbay Cancer Center | Vacaville | California |
| United States | South Georgia Medical Center/Pearlman Cancer Center | Valdosta | Georgia |
| United States | Kaiser Permanente-Vallejo | Vallejo | California |
| United States | Sutter Solano Medical Center/Cancer Center | Vallejo | California |
| United States | PeaceHealth Southwest Medical Center | Vancouver | Washington |
| United States | Essentia Health Virginia Clinic | Virginia | Minnesota |
| United States | University Hospitals Sharon Health Center | Wadsworth | Ohio |
| United States | Kaiser Permanente-Walnut Creek | Walnut Creek | California |
| United States | Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren | Michigan |
| United States | Saint John Macomb-Oakland Hospital | Warren | Michigan |
| United States | South Pointe Hospital | Warrensville Heights | Ohio |
| United States | Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Connecticut |
| United States | Smilow Cancer Hospital Care Center - Waterford | Waterford | Connecticut |
| United States | ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin |
| United States | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin |
| United States | Aspirus Regional Cancer Center | Wausau | Wisconsin |
| United States | Marshfield Clinic-Wausau Center | Wausau | Wisconsin |
| United States | Ascension Medical Group Southeast Wisconsin - Mayfair Road | Wauwatosa | Wisconsin |
| United States | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin |
| United States | Cancer Center of Kansas - Wellington | Wellington | Kansas |
| United States | Aurora West Allis Medical Center | West Allis | Wisconsin |
| United States | Froedtert West Bend Hospital/Kraemer Cancer Center | West Bend | Wisconsin |
| United States | Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan |
| United States | Chester County Hospital | West Chester | Pennsylvania |
| United States | Mercy Medical Center-West Lakes | West Des Moines | Iowa |
| United States | Veterans Affairs Connecticut Healthcare System-West Haven Campus | West Haven | Connecticut |
| United States | Saint Ann's Hospital | Westerville | Ohio |
| United States | UH Seidman Cancer Center at Saint John Medical Center | Westlake | Ohio |
| United States | William E Kahlert Regional Cancer Center/Sinai Hospital | Westminster | Maryland |
| United States | Cleveland Clinic-Weston | Weston | Florida |
| United States | Marshfield Medical Center - Weston | Weston | Wisconsin |
| United States | University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas |
| United States | White River Junction Veteran Administration Medical Center | White River Junction | Vermont |
| United States | Presbyterian Intercommunity Hospital | Whittier | California |
| United States | Ascension Via Christi Hospitals Wichita | Wichita | Kansas |
| United States | Cancer Center of Kansas - Wichita | Wichita | Kansas |
| United States | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas |
| United States | Novant Health Cancer Institute - Wilkesboro | Wilkesboro | North Carolina |
| United States | UPMC Susquehanna | Williamsport | Pennsylvania |
| United States | Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware |
| United States | Shenandoah Oncology PC | Winchester | Virginia |
| United States | Cancer Center of Kansas - Winfield | Winfield | Kansas |
| United States | Novant Health Forsyth Medical Center | Winston-Salem | North Carolina |
| United States | Novant Health Oncology Specialists | Winston-Salem | North Carolina |
| United States | Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin |
| United States | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin |
| United States | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota |
| United States | Woodland Memorial Hospital | Woodland | California |
| United States | Kaiser Permanente-Woodland Hills | Woodland Hills | California |
| United States | Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio |
| United States | UMass Memorial Medical Center - University Campus | Worcester | Massachusetts |
| United States | Lankenau Medical Center | Wynnewood | Pennsylvania |
| United States | Metro Health Hospital | Wyoming | Michigan |
| United States | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington |
| United States | WellSpan Health-York Cancer Center | York | Pennsylvania |
| United States | WellSpan Health-York Hospital | York | Pennsylvania |
| United States | Rush-Copley Healthcare Center | Yorkville | Illinois |
| United States | Huron Gastroenterology PC | Ypsilanti | Michigan |
| United States | IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti | Michigan |
| United States | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio |
| United States | Midwestern Regional Medical Center | Zion | Illinois |
| Lead Sponsor | Collaborator |
|---|---|
| SWOG Cancer Research Network | National Cancer Institute (NCI) |
United States,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Screening Success (Tissue Submission) | The tissue submission will be measured by the proportion of patients who register to this screening study for whom a tissue sample is submitted. | Up to 3 years | |
| Primary | Screening Success (Adequate Tissue) | Adequate tissue will be measured by the proportion of patients who submitted a specimen for whom genomic results were successfully obtained, if multiple platforms are being used (e.g. both FMI and IHC), these rates will be summarized by the individual assays and combined. These rates are summarized for the entire screened population and by screening type (screened at progression versus pre-screened prior to progression). The rates are evaluated for both the initial submission success rates and the overall success rate accounting for new tissue submissions following an unsuccessful result. | Up to 3 years | |
| Primary | Screening Success (Prescreening-to-sub-study Assignment) | Pre-screening-to-sub-study assignment will be measured among pre-screened patients and the proportion of patients assigned to a sub-study (which is triggered by the submission of the notice of progression form, see Section 14.0). Note: Patients screened at progression are notified of their sub-study assignment within 1 day of the biomarker results being reported to SWOG. | Up to 3 years | |
| Primary | Screening Success (Notice of Intention Not to Register Submission) | Screening success will be measured by the reasons for non-participation collection on the LungMAP Notice of Intention not to Register Form. The proportions of patients with this form submitted are summarized overall and by screening type. The reasons for submission are summarized overall and by screening type. | Up to 3 years | |
| Primary | Screening Success (Match to Biomarker-Driven Sub-Study) | Match to Biomarker-Driven Sub-Study will be measured by successful biomarker screening, the proportion assigned to a biomarker-driven substudy. | Up to 3 years | |
| Primary | Screening Success (Assignment Success) | Assignment Success will be measured by the proportion of patients assigned to a sub-study who are registered to a sub-study, these rates are summarized overall and among biomarker-driven and non-match sub-study assignments, separately. In addition, these rates are summarized by screening type. | Up to 3 years |