Modulation of Cognitive Flexibility by Transcranial Direct Current Stimulation, Tyrosine Administration and Polymorphisms in the COMT Gene Clinical Trial
Official title:
Modulation of Cognitive Flexibility by Transcranial Direct Current Stimulation, Tyrosine Administration and Polymorphisms in the COMT Gene
The current study would examine whether increases in endogenous dopaminergic activity via
tyrosine and the (presumed) excitation of these by anodal tDCS of the dlPFC could causally be
related to cognitive flexibility as measured by task switching and reversal learning.
Additionally, the study will test whether the Val158Met-polymorphism in the catechol-
O-methyltransferase (COMT) gene could also predict the effect of TYR supplementation, as this
gene is involved in DA degradation in the prefrontal cortex.
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