Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism Clinical Trial
Official title:
Evaluation of Cerebral Small Vessel Disease in Patient With Primary Aldosteronism
Hypertension is known to be the major risk factor for stroke. The most common cause of
secondary hypertension, primary aldosteronism (PA), is characterized by the excessive
secretion of aldosterone and is related to hypertension and hypokalemia. PA accounts for 3-10
% of hypertensive patients, and a higher incidence of vascular complications compared to
patients with essential hypertension was observed in several studies. The vascular injury
from excessive aldosterone can occur via oxidative stress and collagen remodeling, causing
endothelial dysfunction and fibrosis in the vasculature.
The association between cerebral small vessel disease (cSVD) and hypertension has been well
studies in the past decades. However, not much study has focused on the cSVD burden in
patient with PA. The goal of this study is to understand the features of cSVD in patients
with PA and for the purpose of understanding the underlying pathophysiology of
cerebrovascular injury in this particular patient group.
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