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Reversal of Dual Antiplatelet Therapy With Cold Stored Platelets — R-DAPT  

Bleeding Clinical Trial

Official title:
Reversal of Dual Antiplatelet Therapy With Cold Stored Platelets

Clinical Trial Summary

This study aims to determine whether cold-stored platelets (CSP) are equally, more effective, or uniquely effective at reversing the effect of dual antiplatelet therapy in healthy human subjects compared to room-temperature-stored platelets (RTP). The investigators plan to enroll healthy human subjects without risk factors for bleeding to achieve 60 complete data sets. Each subject will donate two apheresis platelet units. One platelet unit will be stored in the cold (CSP) and one platelet unit will be stored at room temperature (RTP). Subjects will be given dual anti-platelet therapy (aspirin and clopidogrel) prior to autologous transfusion of each unit. Platelet function testing will be performed before and after transfusion to measure reversal of the antiplatelet drugs.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03787927
Study type Interventional
Source Bloodworks
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date December 3, 2018
Completion date December 3, 2021
View Details
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