Skin and Subcutaneous Tissue Disorders Clinical Trial
Official title:
Formulation and Evaluation of Topical Preparation Containing Pomegranate and Ginkgo Biloba for Anti-aging Activities
As the quality of life improves, people are seeking to look as young as they feel. Ginkgo biloba (GB) and Pomegranate (PG) extract can be used to create efficacious topical anti-aging products. GB & PG are now widely used in research and clinical trials on age-associated diseases, for example, skin aging, brain dysfunction, cardiovascular system diseases, carcinogen metabolism. The investigator's aim is to formulate a topical cream in the form (O/W or W/O emulsion) formulation, containing GB as an anti-aging formulation for the public.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | February 28, 2020 |
Est. primary completion date | January 1, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 50 Years to 70 Years |
Eligibility |
Inclusion Criteria: - Clinical diagnosis of aging shape - Follow up and collect data for a local and systemic activity of Ginkgo Biloba and Pomegranate - The skin should be not injured as the cream can be easily applied - Systemic oral capsule Ginkgo Biloba and Pomegranate can be also given to enhance the activity as anti-aging activity Exclusion Criteria: - Insulin-dependent diabetes - Hypertension disease - Skin wound |
Country | Name | City | State |
---|---|---|---|
Egypt | Assiut Clinic | Assiut | |
Saudi Arabia | Faculty of Pharmacy | Buraidah | Qassim |
Saudi Arabia | Pharmaceutics dept., Faculty of Pharmacy, Qassim University | Buraidah | Qassim |
Lead Sponsor | Collaborator |
---|---|
Ahmed A. H. Abdellatif |
Egypt, Saudi Arabia,
Dong LY, Fan L, Li GF, Guo Y, Pan J, Chen ZW. [Anti-aging action of the total lactones of ginkgo on aging mice]. Yao Xue Xue Bao. 2004 Mar;39(3):176-9. Chinese. — View Citation
Kang SJ, Choi BR, Kim SH, Yi HY, Park HR, Song CH, Ku SK, Lee YJ. Beneficial effects of dried pomegranate juice concentrated powder on ultraviolet B-induced skin photoaging in hairless mice. Exp Ther Med. 2017 Aug;14(2):1023-1036. doi: 10.3892/etm.2017.4626. Epub 2017 Jun 16. — View Citation
Rasul A, Akhtar N. Formulation and in vivo evaluation for anti-aging effects of an emulsion containing basil extract using non- invasive biophysical techniques. Daru. 2011;19(5):344-50. — View Citation
Type | Measure | Description | Time frame | Safety issue |
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Primary | Measurement of ant-aging activity of Pomegranate and Ginkgo biloba | The crow's feet wrinkle of 17 volunteers will be measured compared to the control group. The significant results will measure the decrease in the depths of deep furrows for groups treated with Pomegranate and Ginkgo biloba over a three months period. | Three months | |
Secondary | Stable topical anti-aging products for long life shelf storage | Stability test will be studied for dosage forms. The test will be carried out by standing the products on shelf life for six months. The stability test will be recorded using high-performance liquid chromatography each thee days. | Six months |
Status | Clinical Trial | Phase | |
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Completed |
NCT02544165 -
Non Invasive Measurement of the Haemodynamic Parameters and of the Advanced Glycation End Products (AGEs) Levels
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N/A |