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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT03770975
Other study ID # Dinaosamaperio
Secondary ID
Status Not yet recruiting
Phase Phase 3
First received
Last updated
Start date December 1, 2018
Est. completion date May 1, 2020

Study information

Verified date December 2018
Source Cairo University
Contact Dina Osama, Bachelor
Phone 01003808409
Email dina.osama@dentistry.cu.edu.eg
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of this study is to clinically evaluate peri-implant soft tissue esthetics around single delayed implants in the esthetic zone.


Description:

To compare the efficacy of soft tissue augmentation on the peri-implant soft tissue esthetics along with immediate temporization to immediate temporization only.

Population (P): patients with a single missing tooth in the esthetic zone Intervention (I): Delayed implant placement with immediate temporization and subepithelial connective tissue graft Comparator (C): Delayed implant placement with immediate temporization Primary outcome: Pink esthetic score (PES) Time frame: 6 months Study design: Randomized controlled clinical trial


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 22
Est. completion date May 1, 2020
Est. primary completion date December 1, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria:

1. Age > 18 years old

2. Good medical and psychological health

3. Absence of untreated caries lesions and untreated/uncontrolled periodontal disease. If patients required periodontal treatment (non-surgical and/or surgical), this was arranged outside the study protocol and completed at least 30 days prior to the enrolment

4. Need of a single-tooth replacement in the aesthetic (incisor, canine or premolar) region

5. Willingness to sign the informed consent form

Exclusion Criteria:

1. Any known disease (not including controlled diabetes mellitus), infections or recent surgical procedures within 30 days of study initiation;

2. Chronic treatment (i.e., 2 weeks or more) with any medication known to affect oral status (e.g., phenytoin, dihydropyridine, calcium antagonists and cyclosporine) within 1 month before baseline visit;

3. Anticoagulant therapy with warfarin, clopidogrel, ticlopidine or once daily aspirin (more than 81 mg);

4. HIV or Hepatitis;

5. Physical handicaps that would interfere with the ability to perform adequate oral hygiene;

6. Alcoholism or chronic drug abuse;

7. Heavy smokers (>10/cigarettes per day);

8. Lack of adequate primary stability at implant insertion that enables immediate provisionalization (insertion torque ca 30 Ncm).

Study Design


Related Conditions & MeSH terms

  • Immediate Temporization and Soft Tissue Augmentation Around Delayed Implants

Intervention

Procedure:
delayed implant with immediate provisionaliztion and soft tissue graft
delayed implant placement in the esthetic zone with immediate provisinalization and placement of a connective tissue graft buccal
delayed implant placement with immediate provisionalization
delayed implant placement with immediate provisionalization

Locations

Country Name City State
Egypt Faculty of Dentistry, Cairo University Cairo

Sponsors (1)

Lead Sponsor Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

Outcome

Type Measure Description Time frame Safety issue
Primary Pink Esthetic Score Pink esthetic score evaluates the soft tissue esthetics around implant supported crowns. Using a 0-1-2 scoring system, 0 being the lowest, 2 being the highest value. The maximum achievable PES is 14. 7 variables are measured: mesial and distal papillae being 0 if absent, 1 if incomplete and 2 if complete. Alveolar process, soft tissue level, contour, texture and color being 0 if major discrepancy, 1 if minor discrepancy and 2 if matches the contralateral 3 months post definitive prosthesis
Secondary Patient satisfaction by Visual analogue scale (VAS) Patient satisfaction will be evaluated using a questionnaire which is based on a visual analog scale (VAS). A horizontal VAS bar, 100 mm long, with the right anchor labeled "much less than natural teeth" which is marked by zero and the left anchor labeled "much more" which is marked by 10 will be used. Five questions will be formulated to record the patients' satisfaction in terms of functionality and from an esthetic point of view. Participants will look in a mirror and also be viewed a photograph before recording their answers on the horizontal calibrated line. 3 months post definitive
Secondary Buccal peri-implant soft tissue thickness the soft tissue thickness buccal to the implant by using an anesthesia needle and digital caliper 3 months post definitive
Secondary Recession of the buccal peri-implant mucosa measured at the apical zenith of the mucosal margin on the implants after digital superimposition of the optically scanned models as the vertical distance change between the former and the new position of soft tissue margins. 3 months post definitive