Clinical Trial Details
— Status: Withdrawn
Administrative data
| NCT number |
NCT03763305 |
| Other study ID # |
SKNA-TURB |
| Secondary ID |
|
| Status |
Withdrawn |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
January 1, 2023 |
| Est. completion date |
December 31, 2023 |
Study information
| Verified date |
May 2022 |
| Source |
Seoul National University Hospital |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
Skin sympathetic nerve activity (SKNA) has recently been discovered from the
electrocardiogram obtained from healthy volunteers. The raw physiologic electric signal from
electrodes placed on the skin was reprocessed through filtering and integration using
software to produce the SKNA signal. However, no study has yet provided knowledge on the
effect of anesthetics on SKNA during general anesthesia.
Description:
The most commonly used anesthetic techniques during general anesthesia are the total
intravenous anesthesia (TIVA) and anesthesia using inhalants such as sevoflurane or
desflurane. For TIVA, the combination of propofol and remifentanil has been used and
remifentanil is known for increasing vagal tone and inhibiting sympathetic nervous system as
other opioids do. Sevoflurane is presumed to have no effect on parasympathetic or sympathetic
tone. On the other hand, desflurane induces tachycardia and is noted for activating
sympathetic activity. Previous studies on sympathetic nervous activity according to different
anesthetics did not directly measure sympathetic tone but have relied on indirect measures
such as blood pressure, heart rate, and heart rate variability.
In order to evaluate skin sympathetic nerve activity according to different anesthetics, we
will be recruiting patients undergoing transurethral procedures, where the sympathetic tone
is expected to be activated during anesthesia and surgery. The transurethral procedures
consist of transurethral resection of bladder (TURB) and transurethral resection of prostate
(TURP). During transurethral surgery, about 300mL of fluid is used to fill the bladder to
secure surgical view and for irrigation. Bladder expansion causes sympathetic nerve
activation and vasoconstriction, which will also increase SKNA signals. The purpose of this
study is to measure skin sympathetic nerve activity according to different anesthetics during
intraoperative events that stimulate sympathetic tone.
