Main Hypothesis is That in the NASH Associated to IMIDs, to Different Phenotypes co Exist Clinical Trial
Official title:
Immunomediated Non-alcoholic SteaTohepatitis; Prevalence and Characterization. INSTInCT Study
NAFLD is a common comordidity in patients with IMID, including inflammatory bowel disease and
psoriasis.
Nevertheless, the prevalence of NAFLD and NASH in the IMID population is not clear, and the
risk factors are not completely understood. Interestingly, NASH and most of IMIDs share main
molecular and immunological mechanisms of disease, as the inflammatory pathways depending on
TNFa or imbalance in T cell subtypes like Th17/Treg. This common pathogenesis may explain, at
least in a subset of patients, the development of NASH in the absence of classic metabolic
risk factor.
Thus, our main hypothesis is that in the NASH assciated to IMIDs two different phenotypes
co-exist.
First, a predominantly inflammatory phenotype, and not associated to the metabolic syndrome
ande second, a predominantly metabolic phenptype, strongly associated to he metabolic
syndrome.
In this way, we believe that in a particular subset of NAFLD patients, NASH could be
considered as an IMID, as most of the definiting features of IMIDs are present. To
demonstrate our hypothesis, we consider a two-stage study. First, we will determine the NAFLD
and NASH prevalence in a cohort of well-characterized IMID patients and controls. Second, we
will adress the molecular and immunophenotype characterization in liver biopsies of NASH
patients with and without the co-existence of IMIDs.
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