Degenerative Mitral Valve Disease Clinical Trial
Official title:
Clinical and Fundamental Aspects of Prosthetics and Translocation of Mitral Valve Chordae
The study compares the efficacies of two surgical procedures for the treatment of mitral valve prolapse due to myxomatous degeneration of the mitral valve: the chordae replacement and the translocation of secondary mitral valve chordae.
Summary: This study compares the efficacy and the safety of two surgical procedures for the treatment of mitral valve prolapse due to degeneration of the mitral valve: chordae replacement and the translocation of secondary mitral valve chordae. In our study, researchers used the loop method proposed by von Oppel and Mohr in 2000. The main principle of the method of prosthetic chordae is the preservation of the native anatomy of the mitral valve. This principle is achieved by the implantation of artificial chordae made of ePTFE Gore-Tex threads. The chordae replacement method essentially involves five stages: 1. Measuring the required length of the chordae. 2. Forming the loops. 3. Fixation of the group of loops to the papillary muscles. 4. Fixation of the chordal loops to the free edge of the valve. 5. Annuloplasty with a support ring and a hydraulic test to confirm the absence of prolapse. Chordae translocation is the alternative method, which does not require measurement and selection of chordae lengths. Chordae replacement is technically easier (less aortic clamping time) with comparable results. The technique of translocation of secondary chordae essentially consists of three stages: 1. Selection of the secondary chordae. 2. Fixation of secondary chordae to the free edge of the valve. 3. Annuloplasty support ring and hydraulic test to confirm the absence of prolapse. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT03290872 -
Mitral Annuloplasty Rings RCT
|
N/A | |
| Completed |
NCT05774769 -
Commissural Closure to Treat Severe Mitral Regurgitation: Standing the Test of Time.
|
||
| Completed |
NCT05836532 -
Long Term Results of Surgical and Percutaneous Double Orefices Mitral Repair in Patient With p2 Prolapse Causing Degenerative Mitral Regurgitation
|
||
| Completed |
NCT05839782 -
Long Term Results in Redo Mitral Valve Surgery After Mitral Valve Repair
|
||
| Recruiting |
NCT03706833 -
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
|
N/A | |
| Recruiting |
NCT05655897 -
Safety and Efficacy of the GeminiOne Transcatheter Valve Edge-to-Edge Repair System in Patients With Moderate-severe or Severe Degenerative Mitral Regurgitation
|
N/A | |
| Enrolling by invitation |
NCT04734756 -
Safety and Effectiveness Study of Dragonfly System for Degenerative Mitral Regurgitation
|
N/A | |
| Enrolling by invitation |
NCT04067635 -
Primary Mitral Regurgitation Repair
|
||
| Active, not recruiting |
NCT06021509 -
Clinical Study of NovoClasp for Treating Moderate to Severe and Severe Degenerative Mitral Regurgitation
|
N/A | |
| Not yet recruiting |
NCT04679662 -
EXPLORE DMR: Early Feasibility Study of the PLAR Implant and Delivery System to Treat Degenerative Mitral Regurgitation
|
N/A | |
| Active, not recruiting |
NCT04281940 -
Chordal Repair for Transcatheter Mitral Valve Repair (TMVr)
|
N/A | |
| Not yet recruiting |
NCT05417945 -
A Prospective, Multicenter Study to Evaluate the JensClip Transcatheter Valve Repair System
|
N/A | |
| Recruiting |
NCT03433274 -
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
|
N/A | |
| Recruiting |
NCT05595226 -
Effect of RT3D-TEE-guided Mitral Valve Repair on Outcomes in Patients With Degenerative Mitral Valve Disease
|
N/A | |
| Terminated |
NCT04666480 -
Early Feasibility Study of the PLAR Implant and Delivery System to Treat Degenerative Mitral Regurgitation
|
N/A |