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Chemotherapy With Pembrolizumab Continuation After Progression to PD-1/L1 Inhibitors

Non-small Cell Lung Cancer Metastatic Clinical Trial

Official title:
Chemotherapy Plus Pembrolizumab After Progression With Previous PD-1/PD-L1 Inhibitors in Patients With Advanced Non-small Cell Lung Cancer: Placebo-controlled Randomized Phase II Study

Clinical Trial Summary

After progression to previous PD-1/L1 inhibitors (pembrolizumab, nivolumab, or atezolizumab), physicians' choice chemotherapy plus pembolizumab (or placebo) will be administered (3 weeks per cycle) until disease progression or unacceptable toxicity.

Clinical Trial Description

Previous PD-1/PD-L1 inhibitors should be 2nd or 3rd line therapy for advanced NSCLC. There should be no systemic therapy after previous PD-1/PD-L1 therapy, before the enrollment to this study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03656094
Study type Interventional
Source Samsung Medical Center
Contact Jong-Mu Sun
Phone 822-3410-3459
Email jongmu.sun@skku.edu
Status Recruiting
Phase Phase 2
Start date November 1, 2018
Completion date November 1, 2021
View Details
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