24-Wk β-Alanine Ingestion on Muscle Taurine and Clinical Blood Parameters in Healthy Males

Sports Nutritional Physiological Phenomena Clinical Trial

Official title:

24-Weeks of β-Alanine Ingestion on Muscle Taurine and Clinical Blood Parameters in Healthy Males

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03655041
• Other study ID #: 24WKBA
• Status: Completed
• Phase: N/A
• Start date: February 1, 2013
• Est. completion date: December 15, 2017

Study information

• Verified date: August 2018
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Although β-alanine (BA) has been shown to be an effective ergogenic aid, little information exists on the safety of chronic supplementation despite potential concerns. The aim of this study was to investigate the effects of chronic BA supplementation on muscle taurine content, blood clinical markers and sensory side-effects during 24 weeks of BA supplementation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: December 15, 2017
• Est. primary completion date: December 15, 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Healthy males

Exclusion Criteria:

• Smokers

• Chronic disease

• Prior or current use of steroids

• Use of creatine in the last 6 months

• Use of beta-alanine in the last 6 months

Related Conditions & MeSH terms

• Sports Nutritional Physiological Phenomena

Intervention

Dietary Supplement:
• Beta-alanine
Beta-alanine in sustained-release tablets to increase muscle carnosine content
• Placebo
Maltodextrin is used as a placebo as it does not lead to any increases in muscle carnosine

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Sao Paulo

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle taurine content in mmol/kg	Change in the content of taurine in muscle will be determined using High-Pressure Liquid Chromatography of muscle biopsies	Up to 24 weeks
Secondary	Aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase and creatine kinase in U/L	Aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase and creatine kinase will be analysed from venous blood samples	Up to 24 weeks
Secondary	Albumin; globulin; creatinine in mg/dL	Albumin; globulin; creatinine will be analysed from venous blood samples	Up to 24 weeks