Anesthesia Intubation Complication Clinical Trial
Official title:
Co-induction Ketamine-propofol: the Effects on Laryngeal Mask Airway Insertion Conditions and Resulting Hemodynamic Changes in Children
Background: Large doses of propofol needed for induction and laryngeal mask (LM) insertion in
children may be associated with hemodynamic sides effects. Co-induction with low doses of
ketamine 0.5 mg/ kg has the advantage of reducing dose and therefore maintaining hemodynamic
stability.
Aim: To examine the effect of co-induction on LM insertion, hemodynamics and recovery in
children
A prospective, randomized, double-blind, controlled study was conducted including120 ASA physical status I ⁄ II unpremedicated children, aged 1-8 years. Inhalatory induction with sevoflurane at 7% to insert an intravenous canula was first used then decreased to 2%. Normal saline or ketamine (0.5 mg/kg) were administered in groups P (propofol), PK (propofol-ketamine) respectively, 1 min prior to the administration of the induction dose of propofol. Propofol 3mg/kg was used for induction in the 2 groups, LM inserted 60 s later and insertion conditions assessed. Heart rate and blood pressure were recorded immediately after propofol bolus, then after LM insertion, at the 3rd ,5th and 10th minutes later. Recovery was assessed using Steward's Score ;
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