Bile Duct Obstruction, Extrahepatic Clinical Trial
Official title:
Ultrasound-guided Percutaneous Biliary Drainage With Primary Metal Implantation by Endoscopic Luminal Guidance in Patients With Malignant Extrahepatic Bile Duct Obstruction
In a recently published meta-analysis (Sharaiha, Gastrointestinal Endoscopy, 2017), it is
reported that percutaneous transhepatic biliary drainage (PTBD) is less clinical successful,
causes more adverse events and needs more re-interventions than endoscopic ultrasound guided
biliary drainage (EUBD) in patients with malignant, extrahepatic bile duct obstruction. The
conclusion was, that EUBD should be prefered in this clinical setting in future.
An improved technique of PTBD may provide better results for coming comparative studies.
The investigators of this retrospective study therefore analyzed all PTBDs that were
performed in a period of nine years in a tertiary referral hospital. In this cohort, the
analysis focused on PTBDs with primary metal stent implantation by endoscopic luminal
guidance.
When Endoscopic Retrograde Cholangiopancreaticography (ERCP) is not successful or is not
possible to be performed due to anatomical reasons (altered anatomy after abdominal surgery)
in patients with malignant extrahepatic bile duct obstruction, an alternative method is
necessary for biliary drainage. In a recently published meta-analysis (Sharaiha,
Gastrointestinal Endoscopy, 2017), it is reported that percutaneous transhepatic biliary
drainage (PTBD) is less clinical successful, causes more adverse events and needs more
re-interventions than endoscopic ultrasound guided biliary drainage (EUBD) in patients with
malignant, extrahepatic bile duct obstruction. The conclusion was, that EUBD should be
prefered in this clinical setting in future.
An improved technique of PTBD may provide better results for coming comparative studies.
The investigators of this retrospective study therefore analyzed all PTBDs that were
performed in a period of nine years in a tertiary referral hospital. In this cohort, the
analysis focused on PTBDs with primary metal stent implantation by endoscopic luminal
guidance considering technical and clinical success, access route, procedure time,
fluoroscopic time, radiation exposure, adverse events and survival probability in an
observation time of six months.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03030573 -
Reconstruction of the Bile Duct With the Round Ligament
|
N/A | |
| Completed |
NCT03708445 -
Development of a New Immunochemistry Method Using Antibodies of Proteins Related Bile Duct Cancer
|
N/A | |
| Enrolling by invitation |
NCT03951324 -
Volumetric Laser Endomicroscopy's (VLE) Diagnostic Accuracy Validation Study: Impact on Clinical Management Study
|
||
| Recruiting |
NCT03821025 -
Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction
|
N/A | |
| Recruiting |
NCT04759794 -
Clinical Validation of an Immunocytochemistry Method Using MARS1
|
N/A | |
| Recruiting |
NCT03546049 -
Ultrasound-guided Percutaneous Biliary Drainage Versus Endoscopic Ultrasound-guided Biliary Drainage
|
N/A |