Short-term Effects of Tai Chi Chuan Exercise on the Regulation of Lipid and Glucose Metabolisms and Endothelial Function

Physiological Effect of TCC on Glucose Metabolism Clinical Trial

Official title:

The Effect of Tai Chi Chuan on the Endothelin, Insulin, Blood Lipid, Blood Sugar, Aldosterone and Hemodynamics in the Elderly Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03503084
• Other study ID #: V98E2-014
• Status: Completed
• Phase: N/A
• First received: March 30, 2018
• Last updated: April 11, 2018
• Start date: May 1, 2009
• Est. completion date: December 31, 2009

Study information

• Verified date: April 2018
• Source: Changhua Christian Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The short term effects of TCC exercise are the significant increase in serum insulin and insulin resistance, and the significant decrease in serum TC, HDL-C, ET-1 and insulin sensitivity in TCC practitioners. TCC might be benefit the health of its practitioners through the regulation of lipid and glucose metabolism and endothelial function.

Description:

Tai Chi Chuan (TCC) has been shown to be beneficial to the health. However, its effects on lipid and glucose metabolism are not fully understood. This study investigated the short term effect of TCC exercise on lipid and glucose metabolism and endothelial function in TCC practitioners. Twenty-one TCC practitioners and nineteen normal controls were included in this study. The hemodynamics, serum insulin, indices of insulin resistance/sensitivity, serum endothelin-1 (ET-1), blood lipids and aldosterone before and 30 min after a rest or a session of classical Yang's TCC exercise were compared.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: December 31, 2009
• Est. primary completion date: November 30, 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• TCC practitioners in a TCC training center in Taiwan over 50 years of age

• Healthy subjects without TCC experience over 50 years of age

Exclusion Criteria:

• Subjects who had major cardiopulmonary disease

• Subjects who have diabetes mellitus, renal or liver disease

Related Conditions & MeSH terms

• Physiological Effect of TCC on Glucose Metabolism

Intervention

Behavioral:
• Classical Yang's TCC exercise

Locations

Country	Name	City	State
Taiwan	Wan-An Lu	Ilan

Sponsors (2)

Lead Sponsor	Collaborator
Changhua Christian Hospital	Taipei Veterans General Hospital, Taiwan

Country where clinical trial is conducted

Taiwan, 

References & Publications (7)

Couillard C, Després JP, Lamarche B, Bergeron J, Gagnon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C. Effects of endurance exercise training on plasma HDL cholesterol levels depend on levels of triglycerides: evidence from men of the Health, Ris — View Citation

Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000 Jul;85(7):2402-10. — View Citation

Lu WA, Kuo CD. The effect of Tai Chi Chuan on the autonomic nervous modulation in older persons. Med Sci Sports Exerc. 2003 Dec;35(12):1972-6. — View Citation

Lu WA, Kuo CD. Three months of Tai Chi Chuan exercise can reduce serum triglyceride and endothelin-1 in the elderly. Complement Ther Clin Pract. 2013 Nov;19(4):204-8. doi: 10.1016/j.ctcp.2013.06.007. Epub 2013 Jul 27. — View Citation

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 Jul;28(7):412-9. — View Citation

Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E15-26. Epub 2007 Oct 23. Review. — View Citation

Salgado AL, Carvalho Ld, Oliveira AC, Santos VN, Vieira JG, Parise ER. Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals. Arq Gastroenterol. 2010 Apr-Jun;47(2):165-9. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	change in serum triglyceride	change in serum level of triglyceride due to TCC	before and 30 minutes after the completion of TCC exercise
Other	change in serum low density lipoprotein	change in serum level of low density lipoprotein due to TCC	before and 30 minutes after the completion of TCC exercise
Other	change in serum high density lipoprotein	change in serum level of high density lipoprotein due to TCC	before and 30 minutes after the completion of TCC exercise
Other	change in serum insulin	change in serum level of insulin due to TCC	before and 30 minutes after the completion of TCC exercise
Other	change in serum endothelin-1	change in serum level of endothelin-1 due to TCC	before and 30 minutes after the completion of TCC exercise
Other	change in serum aldosterone	change in serum level of aldosterone due to TCC	before and 30 minutes after the completion of TCC exercise
Primary	change in quantitative insulin sensitivity check index	change in insulin sensitivity due to TCC	before and 30 minutes after the completion of TCC exercise
Secondary	change in serum total cholesterol	change in serum total cholesterol due to TCC	before and 30 minutes after the completion of TCC exercise
Secondary	change in homeostasis model assessment-estimated insulin resistance	change in insulin resistance by TCC	before and 30 minutes after the completion of TCC exercise