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NCT03478553 Clinical Trial

The Genetics of Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis (IPF) Clinical Trial

Official title:
Idiopathic Pulmonary Fibrosis, a Disease Initiated by Mucociliary Dysfunction

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03478553
Other study ID # 15-1147
Secondary ID W81XWH-17-1-0597
Status Recruiting
Phase
First received
Last updated
Start date January 18, 2018
Est. completion date December 31, 2026

Study information
Verified date January 2024
Source University of Colorado, Denver
Contact Rachel Warren
Phone 303-724-8569
Email rachel.warren@cuanschutz.edu
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study seeks to screen first degree family members of people with Idiopathic Pulmonary Fibrosis (IPF) for the earliest signs of lung fibrosis.

Description:

The purpose of this study is to explore genetic factors associated with the development of pulmonary fibrosis. The investigators aim is to identify and explore genetic loci that affect development of pulmonary fibrosis and also explore related environmental exposures. Idiopathic pulmonary fibrosis (IPF) is one of the interstitial lung diseases under the broader umbrella of idiopathic interstitial pneumonias (IIP). The investigators hypothesize that inherited genetic factors are associated with pulmonary fibrosis. To investigate the genetics of pulmonary fibrosis, the investigators plan to enroll individuals with pulmonary fibrosis and their family members.

Recruitment information / eligibility
Status Recruiting
Enrollment 1000
Est. completion date December 31, 2026
Est. primary completion date December 31, 2026
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age at least 18 years old - Family member diagnosed with IPF Exclusion Criteria: - No family member with IPF

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Blood draw
Blood draw
• Questionnaire
Pulmonary Fibrosis Questionnaire

Locations
Country Name City State
United States University of Colorado Anschutz Medical Campus Aurora Colorado

Sponsors (1)
Lead Sponsor Collaborator
University of Colorado, Denver

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Identify and explore genetic loci and related environmental exposures in individuals with familial pulmonary fibrosis and their relatives. The investigators aim is to identify and explore genetic loci that affect development of pulmonary fibrosis and also explore related environmental exposures. Idiopathic pulmonary fibrosis (IPF) is one of the interstitial lung diseases under the broader umbrella of idiopathic interstitial pneumonias (IIP). The investigators hypothesize that inherited genetic factors are associated with pulmonary fibrosis. Baseline
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