Pathology of Hepatitis c Nephropathy

Cryoglobulinaemia Due to Chronic Hepatitis C Clinical Trial

Official title:

Different Histopathological Patterns in Patients With HCV Nephropathy

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03476031
• Other study ID #: DHPP
• Status: Not yet recruiting
• First received: March 18, 2018
• Last updated: March 18, 2018
• Start date: November 2018
• Est. completion date: December 2019

Study information

• Verified date: March 2018
• Source: Assiut University
• Contact: Mohammad Tohamy, MD
• Phone: 00201227270775
• Email: proftohammy[@]yahoo.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Hepatitis c associated glomerulonephritis is an immune complex disease that occurs in 21% of patients who have HCV infection.

Description:

Hepatitis C virus infection is a major public health problem with an estimated global prevalence of 3% and an estimated 5-20% of infected patients will develop liver cirrhosis .The Prevalence of Hepatitis C infection in end stage renal disease is greater than in the general population especially in those on hemodialysis which reflects nosocomial transmission of the disease in the hemodialysis environment.

Hepatitis C associated glomerulonephritis is an immune complex disease that occurs in 21% of patients who have HCV infection. It most commonly presents as membranoproliferative and mixed cryoglobulinemia It characterized by an indolent course in one third of patients , remission in another third and relapsing course in the remaining patients with potential progression to advanced chronic kidney disease.

mechanism of injury : Chronic Hepatitis C is primarily associated with type II cryoglobulinemia , in which the primary mechanism of injury is vasculitis that occurs via immune complex deposition.

hepatitis C virus related glomerular disease :

Type I membranoproliferative was the most common finding associated with mixed cryoglobulinemia but other forms of glomerulonephritis were associated with Hepatitis c like mesangial glomerulonephritis,focal and segmental glomerulonephritis,minimal change nephropathy,membranous nephropathy , Fibrillary glomerulonephritis,immunotactoid glomerulopathy,IgA nephropathy, vasculitic renal involvement ,poly arteritis nodosa and interstitial nephritis .

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: December 2019
• Est. primary completion date: October 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 60 Years

Eligibility

Inclusion Criteria:

• it will be conducted on chronic hepatitis C patients with chronic kidney disease .

• The participants will be classified according to their estimated GFR by modified MDRD equation and

• they will be recruited from the renal unit of internal medicine, Assiut University Hospitals and assiut hepatitis viruses unit-ministry of health, Egypt.

Exclusion Criteria:

Patients will be excluded if the underlying causes of CRF are as follows:

chronic pyelonephritis,obstructive uropathy,Polycystic kidney disease,Patients with ESRD on regular hemodialysis,patients with advanced liver cirrhosis,hepatocellular carcinoma,Patients on steroids or immunosuppressive drugs and Solitary kidney.

Related Conditions & MeSH terms

• Cryoglobulinaemia Due to Chronic Hepatitis C
• Cryoglobulinemia
• Hepatitis
• Hepatitis C
• Hepatitis C, Chronic
• Hepatitis, Chronic

Intervention

Diagnostic Test:
• renal biopsy
needle biopsy will be taken from the kidney tissue then, diagnosed

Locations

Country	Name	City	State
Egypt	Assuit University	Assuit

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	prevalence of histopathological pattern in patients with hepatitis C virus	prevalence of histopathological pattern in patients with hepatitis C virus	one year