High-resolution Magnetic Resonance Imaging; Disorders of Consciousness Clinical Trial
Official title:
The Usage of High-resolution Magnetic Resonance Imaging in Patients With Disorders of Consciousness for Early Diagnosis
In this study, high-resolution brain functional magnetic resonance imaging (MRI) was used to evaluate the differences in brain structure and brain function network between patients with different degrees of disturbance of cognition and healthy controls by means of cohort follow-up and control study. The changes of patients' The dynamic changes of learning, to explore its clinical value as an early diagnosis. Combined with neurobehavioral scales and high-resolution brain structure, functional magnetic resonance imaging data to assess the brain structure, functional characteristics and consciousness of patients with impaired consciousness, and initially establish awareness of patients with recovery of consciousness Predictable imaging signs. Twenty eligible controls, 20 VS patients, and 20 MCS patients will be considered for inclusion in the inclusion / exclusion criteria. Informed consent will be obtained as required before starting any registration process.
| Status | Recruiting |
| Enrollment | 60 |
| Est. completion date | January 15, 2020 |
| Est. primary completion date | June 15, 2019 |
| Accepts healthy volunteers | |
| Gender | All |
| Age group | 18 Years to 80 Years |
| Eligibility |
Inclusion Criteria: (1) no use of centrally acting drugs, (2) no use of neuromuscular function blockers and no sedation within the prior 24 h, (3) periods of eye opening indicating a preserved sleep-wake cycle, and (4) a diagnosis of VS or MCS established according to internationally established criteria Exclusion Criteria: Magnetic resonance contraindications |
| Country | Name | City | State |
|---|---|---|---|
| China | Hangzhou Hospital of Zhejiang CAPR | Hangzhou | Zhejiang |
| Lead Sponsor | Collaborator |
|---|---|
| First Affiliated Hospital of Zhejiang University |
China,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Diffusion magnetic resonance imaging analysis | The color-coding of tractography pathways in was determined for a visualization purpose. The color-coding of tractography pathways was based on FA values. | Three months |