Relapsed or Refractory Multiple Myeloma Clinical Trial
Official title:
A Phase 1, Open-Label, Dose-Escalation, Pharmacokinetic, and Pharmacodynamic Study of the Safety and Efficacy of CAR2 Anti-CD38 A2 CAR-T Cells in Patients With Relapsed or Refractory Multiple Myeloma
The study is an open-label Phase 1 single dose-escalation safety study of CAR2 Anti-CD38 A2 CAR-T Cells in patients with Relapsed or Refractory Multiple Myeloma, who meet all other eligibility criteria.
All subjects who received investigational CAR-T therapy will be included in the analyses and summaries of safety, efficacy, pharmacokinetic, and pharmacodynamic assessments. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03837509 -
INCB001158 Combined With Subcutaneous (SC) Daratumumab, Compared to Daratumumab SC, in Relapsed or Refractory Multiple Myeloma
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05519085 -
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
|
Phase 3 | |
| Active, not recruiting |
NCT02099539 -
QUILT-3.005: A Study of ALT-803 in Patients With Relapsed or Refractory Multiple Myeloma
|
Phase 1 | |
| Completed |
NCT00545519 -
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma
|
Phase 1 | |
| Recruiting |
NCT05052970 -
Mitoxantrone Hydrochloride Liposome Injection, Bortezomib and Dexamethasone in the Treatment of R/R MM
|
Phase 1 | |
| Recruiting |
NCT05455320 -
A Study Comparing Talquetamab in Combination With Daratumumab or in Combination With Daratumumab and Pomalidomide Versus Daratumumab in Combination With Pomalidomide and Dexamethasone in Participants With Multiple Myeloma That Returns After Treatment or is Resistant to Treatment
|
Phase 3 | |
| Withdrawn |
NCT05408026 -
Study of Combination POM, BTZ, Low-Dose DEX, and DARA (PVD-DARA) in Patients With RRMM
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT04684108 -
SG301 Safety Study in Subjects With Relapsed or Refractory Multiple Myeloma and Other Hematological Malignancies
|
Phase 1 | |
| Recruiting |
NCT05652335 -
A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis
|
Phase 1 | |
| Completed |
NCT03859427 -
A Study Comparing Once-weekly vs Twice-weekly Carfilzomib in Combination With Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
|
Phase 3 | |
| Completed |
NCT01866293 -
Cabozantinib (XL184) in Patients With Relapsed or Refractory Myeloma
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06375044 -
Study of SIM0500 Alone in Participants With Relapsed or Refractory Multiple Myeloma
|
Phase 1 | |
| Completed |
NCT01058434 -
Safety and Efficacy of TKI258 in Relapsed or Refractory Multiple Myeloma Patients, Who Are With or Without t(4;14) Chromosomal Translocation
|
Phase 2 | |
| Recruiting |
NCT04735575 -
A Ph1/2 Study of EMB-06 in Participants With Relapsed or Refractory Myeloma
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06298266 -
To Assess Safety, Tolerability, and Efficacy of Anti-GPRC5D-CD19-CAR-T in Relapsed/Refractory Multiple Myeloma
|
Early Phase 1 | |
| Recruiting |
NCT05572515 -
A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma
|
Phase 3 | |
| Active, not recruiting |
NCT04798586 -
MAGNETISMM-2: Study of Elranatamab (PF-06863135) in Japanese Participants With Multiple Myeloma
|
Phase 1 | |
| Terminated |
NCT02075021 -
Phase I/II Trial of the Combination of Lenalidomide (Revlimid) and Nab-paclitaxel (Abraxane) in the Treatment of Relapsed/Refractory Multiple Myeloma
|
Phase 1/Phase 2 | |
| Completed |
NCT00478777 -
A Multicenter, Single-Arm, Open-Label Expanded Access Program for Lenalidomide Plus Dexamethasone in Previously Treated Subjects With Multiple Myeloma
|
Phase 3 | |
| Completed |
NCT06082596 -
Study of BEBT-908 in Subjects With Advanced Hematological Tumors
|
Phase 1 |