LMA Versus Mgso4 in Attenuating Stress Response During Emergence of Supratentorial Tumours Patients Clinical Trial
Official title:
A Comparative Study Between Laryngeal Mask Airway and Magensium Sulphate in Attenuating Systemic Stress Response During Emergence of Patients Undergoing Supratentorial Tumours.
Verified date | June 2018 |
Source | Cairo University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
To evaluate the efficacy of replacement of ETT with LMA and administration of Magnesium sulphate at the end of the surgery in attenuating systemic stress response during emergence of patients undergoing supratentorial tumours
Status | Completed |
Enrollment | 60 |
Est. completion date | June 1, 2018 |
Est. primary completion date | May 31, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: 1. ASA physical status I, II. 2. Ages between 18 and 60 years. 3. Body mass index (BMI) < 30. 4. Elective surgery Exclusion Criteria: 1. Patients have cardiovascular, pulmonary, renal, hepatic and endocrine diseases. 2. Patients have any degree of disturbed conscious level. 3. Ages <18 or >60 years. 4. BMI >30. 5. Patients have history of allergy to Magnesium sulphate. 6. Patients have uncontrolled hypertension during preoperative assessment. 7. Patients have risk of aspiration (eg. hiatus hernia) 8. Patients have difficult airway management during intubation with direct laryngoscope or time of intubation >30 seconds. 9. Failed ventilation with LMA. 10. Emergency surgery. |
Country | Name | City | State |
---|---|---|---|
Egypt | Ahmed Abdalla Mohamed | Cairo |
Lead Sponsor | Collaborator |
---|---|
Cairo University | Hamed Fathy Hamed, Mohamed Farid Mohamed, Mohamed, Ahmed A., M.D., Tarek Ahmed Radwan |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mean arterial blood presure | Total dose of nitroglycerin needed in each group to maintain mean blood pressure within 20 % of basal line. | 5 minutes from closure of anesthetics until 15 minutes after extubation | |
Secondary | Intracranial pressure Measurement | Intracranial pressure will be measured at these moments: basal line preinduction, end of surgery, before extubation and 1, 10 minutes after extubation. | 1 and 10 minutes after extubation. | |
Secondary | Quality of extubation | Qualityof extubation will be evaluated based on cough immediately after extubation, using a five point rating scale | Time Onset of cough immediately after extubation | |
Secondary | Level of consciousness | consciousness level will be recorded based on Ramasy score scale at 5 and 15 minutes after extubation, using the following indices | 5 and 15 minutes after extubation | |
Secondary | End of surgery and extubation | Time interval between end of surgery and extubation in each group | intraoperative |