ُEfficacy of Insulin Versus Hyalase Hydro-dissection of Median Nerve in Rheumatoid Arthritis Patients

Treatment Resistant Carpal Tunnel in RA Patients Clinical Trial

Official title:

Treatment of Carpal Tunnel in Rheumatoid Arthritis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03394131
• Other study ID #: Hydrodissection of CT in RA
• Status: Recruiting
• Phase: N/A
• Start date: July 1, 2017
• Est. completion date: August 1, 2018

Study information

• Verified date: July 2018
• Source: Assiut University
• Contact: Manal Hassanien, MD
• Phone: 01062679200
• Email: manal_hassanien[@]yahoo.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy in Rheumatoid arthritis patients proved by nerve conduction studies and ultrasound parameters, this study aims to evaluate the effect of hydro-dissection using insulin versus hyalase versus saline, ultrasounic guided as an effective treatment

Description:

Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy in Rheumatoid arthritis patients proved by nerve conduction studies and ultrasound parameters, this study aims to evaluate the effect of hydro-dissection of median nerve inside CT twice injections with interval 2 weeks using insulin and 10 cc saline versus hyalase and 10 cc saline versus 10 cc saline, ultrasounic guided as an effective treatment of CT

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 90
• Est. completion date: August 1, 2018
• Est. primary completion date: May 1, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Rheumatoid arthritis in remission

Exclusion Criteria:

• active Rheumatoid arthritis

Related Conditions & MeSH terms

• Arthritis, Rheumatoid
• Carpal Tunnel Syndrome
• Treatment Resistant Carpal Tunnel in RA Patients

Intervention

Drug:
• Hylase
hydro-dissection injection of median nerve inside carpal tunnel using hyalase and 10 cc saline
• Insulin
hydro-dissection injection of median nerve inside carpal tunnel using 10 IU insulin and 10 cc saline

Other:
• saline
hydro-dissection injection of median nerve inside carpal tunnel using 10 cc saline

Locations

Country	Name	City	State
Egypt	Manal Hassanien	Assiut	Assuit

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	pain intensity	Visual analog scale 0-100	6 months
Secondary	nerve conduction	sensory velocity	6 months
Secondary	ultrasound	cross sectional area	6 months