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Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015) — ALL-MB 2015  

Childhood Acute Lymphoblastic Leukemia Clinical Trial

Official title:
Moscow-Berlin 2015 Multicenter Randomized Study for Treatment of Acute Lymphoblastic Leukemia in Children, Adolescents and Young Adults

Clinical Trial Summary

QUESTIONS AND OBJECTIVES OF ALL-MB 2015 STUDY

1. Will the new risk group stratification (especially of T-ALL) to improve overall and event-free survival?

2. Will the new protocol is effective and feasible in patients older than 15 years, and especially in young adults?

3. Whether the intermittent dexamethasone administration in induction will result in a decrease in toxicity and mortality without loss of efficacy?

4. Whether the methylprednisolone administration as basic glucocorticoids during induction, consolidation and maintenance therapy will lead to decrease of severe infections and early mortality rate, improve survival and therapy compliance in adolescents and young adults with B-precursor ALL?

5. Whether the administration of Bortezomib in patients with B-precursor ALL with initial WBC≥100,000/µl will improve treatment outcome?

6. Whether the administration of Idarubicin instead Daunorubicin in low-risk T-ALL patients and two-phase induction in intermediate-risk T-ALL patients will reduce relapse rate and improve survival?

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03390387
Study type Interventional
Source Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Contact Alexander I. Karachunskiy, Professor, MD
Phone +7-926-218-84-09
Email info@mbstudy.net
Status Recruiting
Phase N/A
Start date November 2015
Completion date November 2025
View Details
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