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Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation — REAL-GREFFE  

Allogeneic Hematopoietic Stem Cell Transplantation Clinical Trial

Official title:
Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation

Clinical Trial Summary

The study concerns donors and patients receiving allogeneic stem cell haematopoietic transplantation. The aim of the study is to analyse HSC graft content in immune effector T (naive, memory, activated, exhausted) and immunoregulatory cell subtypes (Tregs, iNKT, MDSC) and correlate the results with post-transplant immune reconstitution of those different cell subtypes and clinical events (graft-versus-host-disease, relapse, infections). An ancillary study will focus on the impact of microbiota dysbiosis on post-transplant immune response and regulatory cell subsets.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Allogeneic Hematopoietic Stem Cell Transplantation
Clinical Trial Details
NCT number NCT03357172
Study type Interventional
Source Central Hospital, Nancy, France
Contact Marie-Thérèse RUBIO, PU-PH
Phone 0383153257
Email m.rubio@chru-nancy.fr
Status Recruiting
Phase N/A
Start date October 1, 2019
Completion date September 30, 2026
View Details
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